TY - JOUR
T1 - Decreased serum brain-derived neurotrophic factor in trained men
AU - Nofuji, Yu
AU - Suwa, Masataka
AU - Moriyama, Yoshihiko
AU - Nakano, Hiroshi
AU - Ichimiya, Atsushi
AU - Nishichi, Reiko
AU - Sasaki, Haruka
AU - Radak, Zsolt
AU - Kumagai, Shuzo
PY - 2008/5/23
Y1 - 2008/5/23
N2 - The purpose of this study was to clarify the effect of physical activity on the level of serum brain-derived neurotrophic factor (BDNF). The serum BDNF level in trained men who have participated in regular sport activity (n = 12) was compared to that in sedentary subjects (n = 14). The physical activity levels expressed as total energy expenditure, move-related energy expenditure and walking count in the trained were significantly higher than those in the sedentary. The serum BDNF level in the trained men was found to be lower than that in the sedentary (19.54 ± 4.53 ng/ml vs. 23.63 ± 2.94 ng/ml, respectively, P < 0.01). The serum BDNF level showed a significant negative correlation with daily total energy expenditure (r = -0.507, P < 0.05), movement-related energy expenditure (r = -0.503, P < 0.05), and walking count (r = -0.480, P < 0.05). These results may suggest that vigorous habitual physical activity decrease the serum BDNF level.
AB - The purpose of this study was to clarify the effect of physical activity on the level of serum brain-derived neurotrophic factor (BDNF). The serum BDNF level in trained men who have participated in regular sport activity (n = 12) was compared to that in sedentary subjects (n = 14). The physical activity levels expressed as total energy expenditure, move-related energy expenditure and walking count in the trained were significantly higher than those in the sedentary. The serum BDNF level in the trained men was found to be lower than that in the sedentary (19.54 ± 4.53 ng/ml vs. 23.63 ± 2.94 ng/ml, respectively, P < 0.01). The serum BDNF level showed a significant negative correlation with daily total energy expenditure (r = -0.507, P < 0.05), movement-related energy expenditure (r = -0.503, P < 0.05), and walking count (r = -0.480, P < 0.05). These results may suggest that vigorous habitual physical activity decrease the serum BDNF level.
KW - Brain-derived neurotrophic factor
KW - Energy expenditure
KW - Physical activity
UR - http://www.scopus.com/inward/record.url?scp=42749087606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42749087606&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2008.03.057
DO - 10.1016/j.neulet.2008.03.057
M3 - Article
C2 - 18420345
AN - SCOPUS:42749087606
SN - 0304-3940
VL - 437
SP - 29
EP - 32
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -