Defective phospholipid metabolism in the retinular cell membrane of norpA (no receptor potential) visual transduction mutants of Drosophila

Tohru Yoshioka; Hiroko Inoue; Yoshiki Hotta

doi:10.1016/0006-291X(83)90344-3

Defective phospholipid metabolism in the retinular cell membrane of norpA (no receptor potential) visual transduction mutants of Drosophila

Tohru Yoshioka^*, Hiroko Inoue, Yoshiki Hotta

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The phosphorylation of photoreceptor phospholipids in the three alleles of Drosophila visual mutants (norpA : no receptor potential A gene) was studied. In the normal strain, the γ-³²P of ATP was transferred mainly to phosphatidic acid (PA) and diphosphoinositide (DPI), while, in the mutants, we found that the phosphorylation of PA was drastically reduced, but that of DPI was not. The radioactivity incorporation into PA closely parallels with the degree of the mutant genes' expressivity among the three alleles of norpA tested. Therefore, the abnormality found in the phosphorylation of diglycerol to PA may be closely related to the primary mutant defect in the phototransduction mechanism.

Original language	English
Pages (from-to)	567-573
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	111
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(83)90344-3
Publication status	Published - 1983 Mar 16
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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abstract = "The phosphorylation of photoreceptor phospholipids in the three alleles of Drosophila visual mutants (norpA : no receptor potential A gene) was studied. In the normal strain, the γ-32P of ATP was transferred mainly to phosphatidic acid (PA) and diphosphoinositide (DPI), while, in the mutants, we found that the phosphorylation of PA was drastically reduced, but that of DPI was not. The radioactivity incorporation into PA closely parallels with the degree of the mutant genes' expressivity among the three alleles of norpA tested. Therefore, the abnormality found in the phosphorylation of diglycerol to PA may be closely related to the primary mutant defect in the phototransduction mechanism.",

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AU - Yoshioka, Tohru

AU - Inoue, Hiroko

AU - Hotta, Yoshiki

PY - 1983/3/16

Y1 - 1983/3/16

N2 - The phosphorylation of photoreceptor phospholipids in the three alleles of Drosophila visual mutants (norpA : no receptor potential A gene) was studied. In the normal strain, the γ-32P of ATP was transferred mainly to phosphatidic acid (PA) and diphosphoinositide (DPI), while, in the mutants, we found that the phosphorylation of PA was drastically reduced, but that of DPI was not. The radioactivity incorporation into PA closely parallels with the degree of the mutant genes' expressivity among the three alleles of norpA tested. Therefore, the abnormality found in the phosphorylation of diglycerol to PA may be closely related to the primary mutant defect in the phototransduction mechanism.

AB - The phosphorylation of photoreceptor phospholipids in the three alleles of Drosophila visual mutants (norpA : no receptor potential A gene) was studied. In the normal strain, the γ-32P of ATP was transferred mainly to phosphatidic acid (PA) and diphosphoinositide (DPI), while, in the mutants, we found that the phosphorylation of PA was drastically reduced, but that of DPI was not. The radioactivity incorporation into PA closely parallels with the degree of the mutant genes' expressivity among the three alleles of norpA tested. Therefore, the abnormality found in the phosphorylation of diglycerol to PA may be closely related to the primary mutant defect in the phototransduction mechanism.

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Defective phospholipid metabolism in the retinular cell membrane of norpA (no receptor potential) visual transduction mutants of Drosophila

Abstract

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