Defective phospholipid metabolism in the retinular cell membrane of norpA (no receptor potential) visual transduction mutants of Drosophila

Tohru Yoshioka, Hiroko Inoue, Yoshiki Hotta

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The phosphorylation of photoreceptor phospholipids in the three alleles of Drosophila visual mutants (norpA : no receptor potential A gene) was studied. In the normal strain, the γ-32P of ATP was transferred mainly to phosphatidic acid (PA) and diphosphoinositide (DPI), while, in the mutants, we found that the phosphorylation of PA was drastically reduced, but that of DPI was not. The radioactivity incorporation into PA closely parallels with the degree of the mutant genes' expressivity among the three alleles of norpA tested. Therefore, the abnormality found in the phosphorylation of diglycerol to PA may be closely related to the primary mutant defect in the phototransduction mechanism.

Original languageEnglish
Pages (from-to)567-573
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume111
Issue number2
DOIs
Publication statusPublished - 1983 Mar 16
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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