Delayed vagal withdrawal slows circulatory but not oxygen uptake responses at work increase

Naoyuki Hayashi, Ayumu Tanaka, Mutsuhisa Ishihara, Takayoshi Yoshida

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The effect of delayed vagal activity withdrawal on cardiorespiratory responses at an increase in workload was examined. Eleven volunteers (21 ± 3 yr, 66 ± 4 kg) performed cycle ergometer exercise at a work rate corresponding to 80% of ventilatery threshold after 3 min of unloaded cycling. Facial stimulation was given by applying a vinyl bag filled with cold water (3-5°C) to the face 1 min before to 1 min after the increase in workload (S2 trial) or no stimulation was given (Nr trial). Oxygen uptake (Vo2), heart rate (HR), and cardiac output (Q) were continuously recorded in four transitions for each trial. Data were averaged for each subject and trial. Mean response time (MRT, sum of delay and time constant) was calculated with a monoexponential fitting. Facial stimulation induced acute bradycardia (- 10 ± 5 beats/min in S2 trial). The MRT of HR and Q was significantly longer in the S2 trials (46 ± 35 and 37 ± 23 s) than in the Nr trials (26 ± 18 and 28 ± 9 s, respectively), but no significant change in Vo2 MRT was shown (36 ± 7 vs. 38 ± 12 s). These findings suggest that increased vagal activity delays the central circulatory responses, which does not alter the Vo2 kinetics at the onset of stepwise increase in workload. The maintenance of Vo2 kinetics during acute bradycardia may either reflect the fact that some intramuscular processes (such as oxidative enzyme inertia) limit Vo2 kinetics or alternatively that increased sympathetic vasoconstriction at some remote site defends exercising muscle blood flow.

Original languageEnglish
Pages (from-to)R1268-R1273
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume274
Issue number5 43-5
DOIs
Publication statusPublished - 1998 May
Externally publishedYes

Keywords

  • Cardiac output
  • Diving reflex
  • Heart rate
  • Oxygen uptake kinetics
  • Vagal activation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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