Depression and outcomes in hospitalized japanese patients with cardiovascular disease

Prospective single-center observational study

Tsuyoshi Suzuki, Tsuyoshi Shiga, Kazue Kuwahara, Sayaka Kobayashi, Shinichi Suzuki, Katsuji Nishimura, Atsushi Suzuki, Hisako Omori, Fumiaki Mori, Jun Ishigooka, Hiroshi Kasanuki, Nobuhisa Hagiwara

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Background: Several studies have suggested that depression poses a risk in cardiovascular patients. The aim of the present study was to evaluate the prevalence of depression and its effect on cardiovascular events and mortality in Japanese inpatients with cardiovascular disease. Methods and Results: A total of 505 patients hospitalized with cardiovascular disease (28% female; mean age, 61±14 years; 31% ischemic heart disease; 47% New York Heart Association [NYHA] class II-IV; 25% implantation of pacing devices) were enrolled in the present prospective observational study. The Zung Self-Rating Depression Scale (SDS) was used to screen for depression. The primary outcome was the time to death or cardiovascular event, and the secondary outcome was death. In total, 109 patients (22%) were diagnosed with depression (Zung SDS index score ≥60). NYHA class III/IV, defibrillator implantation, and being unmarried were independently associated with depression. During an average follow-up period of 38±15 months, 92 patients (18%) reached the primary out- come. There was a higher incidence of the primary outcome in patients with depression than in those who were not depressed (P<0.01). Depressed patients had a significantly higher rate of mortality than non-depressed patients (P<0.01). Depression was an independent predictor of the primary outcome (hazard ratio, 2.25; 95% confidence interval: 1.30-3.92, P<0.01). Conclusions: Depression was not uncommon in Japanese inpatients with cardiovascular disease and was associated with cardiovascular outcomes.

    Original languageEnglish
    Pages (from-to)2465-2473
    Number of pages9
    JournalCirculation Journal
    Volume75
    Issue number10
    DOIs
    Publication statusPublished - 2011 Oct

    Fingerprint

    Observational Studies
    Cardiovascular Diseases
    Depression
    Inpatients
    Defibrillators
    Mortality
    Myocardial Ischemia
    Prospective Studies
    Confidence Intervals
    Equipment and Supplies
    Incidence

    Keywords

    • Cardiovascular disease
    • Depression
    • Inpatient
    • Mortality
    • Outcome

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Depression and outcomes in hospitalized japanese patients with cardiovascular disease : Prospective single-center observational study. / Suzuki, Tsuyoshi; Shiga, Tsuyoshi; Kuwahara, Kazue; Kobayashi, Sayaka; Suzuki, Shinichi; Nishimura, Katsuji; Suzuki, Atsushi; Omori, Hisako; Mori, Fumiaki; Ishigooka, Jun; Kasanuki, Hiroshi; Hagiwara, Nobuhisa.

    In: Circulation Journal, Vol. 75, No. 10, 10.2011, p. 2465-2473.

    Research output: Contribution to journalArticle

    Suzuki, T, Shiga, T, Kuwahara, K, Kobayashi, S, Suzuki, S, Nishimura, K, Suzuki, A, Omori, H, Mori, F, Ishigooka, J, Kasanuki, H & Hagiwara, N 2011, 'Depression and outcomes in hospitalized japanese patients with cardiovascular disease: Prospective single-center observational study', Circulation Journal, vol. 75, no. 10, pp. 2465-2473. https://doi.org/10.1253/circj.CJ-11-0140
    Suzuki, Tsuyoshi ; Shiga, Tsuyoshi ; Kuwahara, Kazue ; Kobayashi, Sayaka ; Suzuki, Shinichi ; Nishimura, Katsuji ; Suzuki, Atsushi ; Omori, Hisako ; Mori, Fumiaki ; Ishigooka, Jun ; Kasanuki, Hiroshi ; Hagiwara, Nobuhisa. / Depression and outcomes in hospitalized japanese patients with cardiovascular disease : Prospective single-center observational study. In: Circulation Journal. 2011 ; Vol. 75, No. 10. pp. 2465-2473.
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    T1 - Depression and outcomes in hospitalized japanese patients with cardiovascular disease

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    AU - Suzuki, Tsuyoshi

    AU - Shiga, Tsuyoshi

    AU - Kuwahara, Kazue

    AU - Kobayashi, Sayaka

    AU - Suzuki, Shinichi

    AU - Nishimura, Katsuji

    AU - Suzuki, Atsushi

    AU - Omori, Hisako

    AU - Mori, Fumiaki

    AU - Ishigooka, Jun

    AU - Kasanuki, Hiroshi

    AU - Hagiwara, Nobuhisa

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    N2 - Background: Several studies have suggested that depression poses a risk in cardiovascular patients. The aim of the present study was to evaluate the prevalence of depression and its effect on cardiovascular events and mortality in Japanese inpatients with cardiovascular disease. Methods and Results: A total of 505 patients hospitalized with cardiovascular disease (28% female; mean age, 61±14 years; 31% ischemic heart disease; 47% New York Heart Association [NYHA] class II-IV; 25% implantation of pacing devices) were enrolled in the present prospective observational study. The Zung Self-Rating Depression Scale (SDS) was used to screen for depression. The primary outcome was the time to death or cardiovascular event, and the secondary outcome was death. In total, 109 patients (22%) were diagnosed with depression (Zung SDS index score ≥60). NYHA class III/IV, defibrillator implantation, and being unmarried were independently associated with depression. During an average follow-up period of 38±15 months, 92 patients (18%) reached the primary out- come. There was a higher incidence of the primary outcome in patients with depression than in those who were not depressed (P<0.01). Depressed patients had a significantly higher rate of mortality than non-depressed patients (P<0.01). Depression was an independent predictor of the primary outcome (hazard ratio, 2.25; 95% confidence interval: 1.30-3.92, P<0.01). Conclusions: Depression was not uncommon in Japanese inpatients with cardiovascular disease and was associated with cardiovascular outcomes.

    AB - Background: Several studies have suggested that depression poses a risk in cardiovascular patients. The aim of the present study was to evaluate the prevalence of depression and its effect on cardiovascular events and mortality in Japanese inpatients with cardiovascular disease. Methods and Results: A total of 505 patients hospitalized with cardiovascular disease (28% female; mean age, 61±14 years; 31% ischemic heart disease; 47% New York Heart Association [NYHA] class II-IV; 25% implantation of pacing devices) were enrolled in the present prospective observational study. The Zung Self-Rating Depression Scale (SDS) was used to screen for depression. The primary outcome was the time to death or cardiovascular event, and the secondary outcome was death. In total, 109 patients (22%) were diagnosed with depression (Zung SDS index score ≥60). NYHA class III/IV, defibrillator implantation, and being unmarried were independently associated with depression. During an average follow-up period of 38±15 months, 92 patients (18%) reached the primary out- come. There was a higher incidence of the primary outcome in patients with depression than in those who were not depressed (P<0.01). Depressed patients had a significantly higher rate of mortality than non-depressed patients (P<0.01). Depression was an independent predictor of the primary outcome (hazard ratio, 2.25; 95% confidence interval: 1.30-3.92, P<0.01). Conclusions: Depression was not uncommon in Japanese inpatients with cardiovascular disease and was associated with cardiovascular outcomes.

    KW - Cardiovascular disease

    KW - Depression

    KW - Inpatient

    KW - Mortality

    KW - Outcome

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