Design a novel asymmetric bifurcating microfluidic channel for cell separation by size

Zhonggang Feng, Takao Nakamura, Daisuke Sato, Tatsuo Kitajima, Mitsuo Umezu

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    In this paper, we exhibit a novel asymmetric bifurcating microchannel for cell separation by size. As developing this microchannel, we proposed the design and optimization criteria, which included the design of inlet and outlet based on the analysis of the Segre-Silberberg effect and the optimization principle to render the migration force at the bifurcation portion as great as possible. Experiments using rat fibroblasts and red blood cells verified these design principles and confirmed the separation function with the optimal design. The simple configuration of the microchannel makes it feasible to serialize several such microchannels within 1.0×1.0 mm2 space and to achieve enrichment rate as high as 103∼104 folds.

    Original languageEnglish
    Title of host publication2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    ISBN (Print)9781479978625
    DOIs
    Publication statusPublished - 2015 Sep 8
    Event10th Asian Control Conference, ASCC 2015 - Kota Kinabalu, Malaysia
    Duration: 2015 May 312015 Jun 3

    Other

    Other10th Asian Control Conference, ASCC 2015
    CountryMalaysia
    CityKota Kinabalu
    Period15/5/3115/6/3

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    Keywords

    • asymmetric bifurcation
    • cell separation
    • cell size
    • label-free
    • microfluidics

    ASJC Scopus subject areas

    • Control and Systems Engineering

    Cite this

    Feng, Z., Nakamura, T., Sato, D., Kitajima, T., & Umezu, M. (2015). Design a novel asymmetric bifurcating microfluidic channel for cell separation by size. In 2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015 [7244477] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ASCC.2015.7244477