Design a novel asymmetric bifurcating microfluidic channel for cell separation by size

Zhonggang Feng; Takao Nakamura; Daisuke Sato; Tatsuo Kitajima; Mitsuo Umezu

doi:10.1109/ASCC.2015.7244477

Design a novel asymmetric bifurcating microfluidic channel for cell separation by size

Zhonggang Feng, Takao Nakamura, Daisuke Sato, Tatsuo Kitajima, Mitsuo Umezu

School of Creative Science and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this paper, we exhibit a novel asymmetric bifurcating microchannel for cell separation by size. As developing this microchannel, we proposed the design and optimization criteria, which included the design of inlet and outlet based on the analysis of the Segre-Silberberg effect and the optimization principle to render the migration force at the bifurcation portion as great as possible. Experiments using rat fibroblasts and red blood cells verified these design principles and confirmed the separation function with the optimal design. The simple configuration of the microchannel makes it feasible to serialize several such microchannels within 1.0×1.0 mm² space and to achieve enrichment rate as high as 10³∼10⁴ folds.

Original language	English
Title of host publication	2015 10th Asian Control Conference
Subtitle of host publication	Emerging Control Techniques for a Sustainable World, ASCC 2015
Editors	Hazlina Selamat, Hafiz Rashidi Haruna Ramli, Ahmad Athif Mohd Faudzi, Ribhan Zafira Abdul Rahman, Asnor Juraiza Ishak, Azura Che Soh, Siti Anom Ahmad
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479978625
DOIs	https://doi.org/10.1109/ASCC.2015.7244477
Publication status	Published - 2015 Sept 8
Event	10th Asian Control Conference, ASCC 2015 - Kota Kinabalu, Malaysia Duration: 2015 May 31 → 2015 Jun 3

Publication series

Name	2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015

Other

Other	10th Asian Control Conference, ASCC 2015
Country/Territory	Malaysia
City	Kota Kinabalu
Period	15/5/31 → 15/6/3

Keywords

asymmetric bifurcation
cell separation
cell size
label-free
microfluidics

ASJC Scopus subject areas

Control and Systems Engineering

Access to Document

10.1109/ASCC.2015.7244477

Cite this

Feng, Z., Nakamura, T., Sato, D., Kitajima, T., & Umezu, M. (2015). Design a novel asymmetric bifurcating microfluidic channel for cell separation by size. In H. Selamat, H. R. H. Ramli, A. A. M. Faudzi, R. Z. A. Rahman, A. J. Ishak, A. C. Soh, & S. A. Ahmad (Eds.), 2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015 [7244477] (2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ASCC.2015.7244477

Design a novel asymmetric bifurcating microfluidic channel for cell separation by size. / Feng, Zhonggang; Nakamura, Takao; Sato, Daisuke et al.

2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015. ed. / Hazlina Selamat; Hafiz Rashidi Haruna Ramli; Ahmad Athif Mohd Faudzi; Ribhan Zafira Abdul Rahman; Asnor Juraiza Ishak; Azura Che Soh; Siti Anom Ahmad. Institute of Electrical and Electronics Engineers Inc., 2015. 7244477 (2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Feng, Z, Nakamura, T, Sato, D, Kitajima, T & Umezu, M 2015, Design a novel asymmetric bifurcating microfluidic channel for cell separation by size. in H Selamat, HRH Ramli, AAM Faudzi, RZA Rahman, AJ Ishak, AC Soh & SA Ahmad (eds), 2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015., 7244477, 2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015, Institute of Electrical and Electronics Engineers Inc., 10th Asian Control Conference, ASCC 2015, Kota Kinabalu, Malaysia, 15/5/31. https://doi.org/10.1109/ASCC.2015.7244477

Feng Z, Nakamura T, Sato D, Kitajima T, Umezu M. Design a novel asymmetric bifurcating microfluidic channel for cell separation by size. In Selamat H, Ramli HRH, Faudzi AAM, Rahman RZA, Ishak AJ, Soh AC, Ahmad SA, editors, 2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7244477. (2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015). doi: 10.1109/ASCC.2015.7244477

Feng, Zhonggang ; Nakamura, Takao ; Sato, Daisuke et al. / Design a novel asymmetric bifurcating microfluidic channel for cell separation by size. 2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015. editor / Hazlina Selamat ; Hafiz Rashidi Haruna Ramli ; Ahmad Athif Mohd Faudzi ; Ribhan Zafira Abdul Rahman ; Asnor Juraiza Ishak ; Azura Che Soh ; Siti Anom Ahmad. Institute of Electrical and Electronics Engineers Inc., 2015. (2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015).

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abstract = "In this paper, we exhibit a novel asymmetric bifurcating microchannel for cell separation by size. As developing this microchannel, we proposed the design and optimization criteria, which included the design of inlet and outlet based on the analysis of the Segre-Silberberg effect and the optimization principle to render the migration force at the bifurcation portion as great as possible. Experiments using rat fibroblasts and red blood cells verified these design principles and confirmed the separation function with the optimal design. The simple configuration of the microchannel makes it feasible to serialize several such microchannels within 1.0×1.0 mm2 space and to achieve enrichment rate as high as 103∼104 folds.",

keywords = "asymmetric bifurcation, cell separation, cell size, label-free, microfluidics",

author = "Zhonggang Feng and Takao Nakamura and Daisuke Sato and Tatsuo Kitajima and Mitsuo Umezu",

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AU - Umezu, Mitsuo

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AB - In this paper, we exhibit a novel asymmetric bifurcating microchannel for cell separation by size. As developing this microchannel, we proposed the design and optimization criteria, which included the design of inlet and outlet based on the analysis of the Segre-Silberberg effect and the optimization principle to render the migration force at the bifurcation portion as great as possible. Experiments using rat fibroblasts and red blood cells verified these design principles and confirmed the separation function with the optimal design. The simple configuration of the microchannel makes it feasible to serialize several such microchannels within 1.0×1.0 mm2 space and to achieve enrichment rate as high as 103∼104 folds.

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Design a novel asymmetric bifurcating microfluidic channel for cell separation by size

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