Design and fabrication of a flexible glucose sensing platform toward rapid battery-free detection of hyperglycaemia

Hajime Fujita, Kento Yamagishi, Wenshen Zhou, Yu Tahara, Shao Ying Huang, Michinao Hashimoto, Toshinori Fujie

Research output: Contribution to journalArticlepeer-review

Abstract

The rapid detection of postprandial hyperglycaemia (PPHG) is imperative for the diagnosis of diabetes and the assessment of health risks for nondiabetics. Battery-free flexible glucose sensors are a promising tool for glucose sensing with a relatively low burden on biological tissues and living bodies because they are more lightweight and flexible than conventional battery-driven glucose sensors. However, existing battery-free glucose sensors are unsuitable for the practical detection of hyperglycaemia because of their long response time (>1 h) and response fluctuation. In this research, we demonstrated a unique combination of materials and device design—phenylboronic acid (PBA) hydrogel integrated with an inkjet-printed interdigitated capacitor (IDC)—that enabled rapid response to the change in the glucose concentration. In particular, the following three essential capabilities have been demonstrated: (1) quick response time (<5 min) to mouse serum under hyperglycaemia in a battery-free setting, (2) conformability of soft PBA hydrogel suitable for use on biological surfaces, and (3) controlled design of the signal transducer enabled by digital fabrication. We believe that these capabilities serve as core technologies toward the development of tissue-interfaced battery-free glucose sensors with improved response time.

Original languageEnglish
Pages (from-to)7336-7344
Number of pages9
JournalJournal of Materials Chemistry C
Volume9
Issue number23
DOIs
Publication statusPublished - 2021 Jun 21

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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