Design of a sedimentation hole in a microfluidic channel to remove blood cells from diluted whole blood

Chiaki Kuroda, Yoshimichi Ohki, Hiroki Ashiba, Makoto Fujimaki, Koichi Awazu, Makoto Makishima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

With the aim of developing a sensor for rapidly detecting viruses in a drop of blood, in this study, we analyze the shape of a hole in a microfluidic channel in relation to the efficiency of sedimentation of blood cells. The efficiency of sedimentation is examined on the basis of our calculation and experimental results for two types of sedimentation hole, cylindrical and truncated conical holes, focusing on the Boycott effect, which can promote the sedimentation of blood cells from a downward-facing wall. As a result, we demonstrated that blood cells can be eliminated with an efficiency of 99% or higher by retaining a diluted blood sample of about 30 μL in the conical hole for only 2 min. Moreover, we succeeded in detecting the antihepatitis B surface antigen antibody in blood using a waveguide-mode sensor equipped with a microfluidic channel having the conical sedimentation hole.

Original languageEnglish
Article number037201
JournalJapanese journal of applied physics
Volume56
Issue number3
DOIs
Publication statusPublished - 2017 Mar

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Design of a sedimentation hole in a microfluidic channel to remove blood cells from diluted whole blood'. Together they form a unique fingerprint.

Cite this