Design of constant supersaturation cooling crystallization of a pharmaceutical

A simple approach

Keigo Hanaki, Nobuaki Nonoyama, Yasuaki Yabuki, Yoshiaki Kato, Izumi Hirasawa

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.

    Original languageEnglish
    Pages (from-to)63-71
    Number of pages9
    JournalJournal of Chemical Engineering of Japan
    Volume40
    Issue number1
    DOIs
    Publication statusPublished - 2007 Jan 19

    Fingerprint

    Supersaturation
    Crystallization
    Drug products
    Cooling
    Pharmaceutical Preparations
    Crystal growth
    Rate constants
    Solubility
    Experiments
    Trajectories
    Temperature

    Keywords

    • Constant supersaturation
    • Cooling
    • Crystal growth
    • Crystallization

    ASJC Scopus subject areas

    • Chemical Engineering(all)

    Cite this

    Design of constant supersaturation cooling crystallization of a pharmaceutical : A simple approach. / Hanaki, Keigo; Nonoyama, Nobuaki; Yabuki, Yasuaki; Kato, Yoshiaki; Hirasawa, Izumi.

    In: Journal of Chemical Engineering of Japan, Vol. 40, No. 1, 19.01.2007, p. 63-71.

    Research output: Contribution to journalArticle

    Hanaki, Keigo ; Nonoyama, Nobuaki ; Yabuki, Yasuaki ; Kato, Yoshiaki ; Hirasawa, Izumi. / Design of constant supersaturation cooling crystallization of a pharmaceutical : A simple approach. In: Journal of Chemical Engineering of Japan. 2007 ; Vol. 40, No. 1. pp. 63-71.
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