Design of constant supersaturation cooling crystallization of a pharmaceutical: A simple approach

Keigo Hanaki, Nobuaki Nonoyama, Yasuaki Yabuki, Yoshiaki Kato, Izumi Hirasawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.

Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalJOURNAL OF CHEMICAL ENGINEERING OF JAPAN
Volume40
Issue number1
DOIs
Publication statusPublished - 2007 Jan 19

Keywords

  • Constant supersaturation
  • Cooling
  • Crystal growth
  • Crystallization

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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