Abstract
This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.
| Original language | English |
|---|---|
| Pages (from-to) | 63-71 |
| Number of pages | 9 |
| Journal | Journal of Chemical Engineering of Japan |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 Jan 19 |
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Keywords
- Constant supersaturation
- Cooling
- Crystal growth
- Crystallization
ASJC Scopus subject areas
- Chemical Engineering(all)
Cite this
Design of constant supersaturation cooling crystallization of a pharmaceutical : A simple approach. / Hanaki, Keigo; Nonoyama, Nobuaki; Yabuki, Yasuaki; Kato, Yoshiaki; Hirasawa, Izumi.
In: Journal of Chemical Engineering of Japan, Vol. 40, No. 1, 19.01.2007, p. 63-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design of constant supersaturation cooling crystallization of a pharmaceutical
T2 - A simple approach
AU - Hanaki, Keigo
AU - Nonoyama, Nobuaki
AU - Yabuki, Yasuaki
AU - Kato, Yoshiaki
AU - Hirasawa, Izumi
PY - 2007/1/19
Y1 - 2007/1/19
N2 - This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.
AB - This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.
KW - Constant supersaturation
KW - Cooling
KW - Crystal growth
KW - Crystallization
UR - http://www.scopus.com/inward/record.url?scp=33846496685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846496685&partnerID=8YFLogxK
U2 - 10.1252/jcej.40.63
DO - 10.1252/jcej.40.63
M3 - Article
VL - 40
SP - 63
EP - 71
JO - Journal of Chemical Engineering of Japan
JF - Journal of Chemical Engineering of Japan
SN - 0021-9592
IS - 1
ER -