Abstract
This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.
Original language | English |
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Pages (from-to) | 63-71 |
Number of pages | 9 |
Journal | JOURNAL OF CHEMICAL ENGINEERING OF JAPAN |
Volume | 40 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2007 Jan 19 |
Keywords
- Constant supersaturation
- Cooling
- Crystal growth
- Crystallization
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)