Design of microstructure for stimulating mechanical torque to cells

Hiroaki Nagase, Eiji Iwase

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we proposed the design for microstructure which can apply bending or torsion stimulus to cell using an external magnetic field. First, we defined “ideal bending stimulus” and “ideal torsion stimulus” for cell on a microstructure. In order to apply ideal bending or torsion stimulus to cells, the thickness of the microstructure of cell-culturing region is important. We designed and microfabricated the microstructure which consists of a thin silicon beam as cell-culturing region and a ferromagnetic material, nickel film for magneto-active structure. Then, fabricated microstructures actuated by external magnetic field and deformation of the microstructures was measured. From the results of the measurements, we calculated radius of curvature and angle of torsion respectively and we confirmed the platform almost actuated in theory. Our design of the platform can contribute to applying new kinds of mechanical stimuli to cultured cells.

Original languageEnglish
Title of host publicationBIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019
EditorsAna Roque, Ana Fred, Hugo Gamboa
PublisherSciTePress
Pages215-219
Number of pages5
ISBN (Electronic)9789897583537
Publication statusPublished - 2019 Jan 1
Event12th International Conference on Biomedical Electronics and Devices, BIODEVICES 2019 - Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019 - Prague, Czech Republic
Duration: 2019 Feb 222019 Feb 24

Publication series

NameBIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019

Conference

Conference12th International Conference on Biomedical Electronics and Devices, BIODEVICES 2019 - Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019
CountryCzech Republic
CityPrague
Period19/2/2219/2/24

Fingerprint

Torque
Torsional stress
Microstructure
Magnetic fields
Ferromagnetic materials
Nickel
Cells
Silicon

Keywords

  • Bending Stimulus
  • Mechanobiology
  • Micro-Electro-Mechanical Systems (MEMS)
  • Torsion Stimulus

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Nagase, H., & Iwase, E. (2019). Design of microstructure for stimulating mechanical torque to cells. In A. Roque, A. Fred, & H. Gamboa (Eds.), BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019 (pp. 215-219). (BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019). SciTePress.

Design of microstructure for stimulating mechanical torque to cells. / Nagase, Hiroaki; Iwase, Eiji.

BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. ed. / Ana Roque; Ana Fred; Hugo Gamboa. SciTePress, 2019. p. 215-219 (BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nagase, H & Iwase, E 2019, Design of microstructure for stimulating mechanical torque to cells. in A Roque, A Fred & H Gamboa (eds), BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019, SciTePress, pp. 215-219, 12th International Conference on Biomedical Electronics and Devices, BIODEVICES 2019 - Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019, Prague, Czech Republic, 19/2/22.
Nagase H, Iwase E. Design of microstructure for stimulating mechanical torque to cells. In Roque A, Fred A, Gamboa H, editors, BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. SciTePress. 2019. p. 215-219. (BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019).
Nagase, Hiroaki ; Iwase, Eiji. / Design of microstructure for stimulating mechanical torque to cells. BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. editor / Ana Roque ; Ana Fred ; Hugo Gamboa. SciTePress, 2019. pp. 215-219 (BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019).
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