Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering

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    52 Citations (Scopus)

    Abstract

    Collagens, characterized by a unique triple-helical structure, are the predominant component of extracellular matrices (ECMs) existing in all multicellular animals. Collagens not only maintain structural integrity of tissues and organs, but also regulate a number of biological events, including cell attachment, migration and differentiation, tissue regeneration and animal development. The specific functions of collagens are generally triggered by specific interactions of collagen-binding molecules (membrane receptors, soluble factors and other ECM components) with certain structures displayed on the collagen triple helices. Thus, synthetic triple-helical peptides that mimic the structure of native collagens have been used to investigate the individual collagen-protein interactions, as well as collagen structure and stability. The first part of this article illustrates the design of various collagen-mimetic peptides and their recent applications in matrix biology. Collagen is also acknowledged as one of the most promising biomaterials in regenerative medicine and tissue engineering. However, the use of animal-derived collagens in human could put the recipients at risks of pathogen transmission or allergic reactions. Hence, the production of safe artificial collagen surrogates is currently of considerable interest. The latter part of this article reviews recent attempts to develop artificial collagens as novel biomaterials.

    Original languageEnglish
    Pages (from-to)1281-1291
    Number of pages11
    JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
    Volume362
    Issue number1484
    DOIs
    Publication statusPublished - 2007 Aug 29

    Fingerprint

    Biochemistry
    collagen
    biochemistry
    peptide
    engineering
    Collagen
    peptides
    Peptides
    matrix
    Animals
    biocompatible materials
    Biocompatible Materials
    extracellular matrix
    Extracellular Matrix
    animal
    tissue engineering
    animal development
    Tissue regeneration
    Infectious Disease Transmission
    Regenerative Medicine

    Keywords

    • Biomaterial
    • Collagen
    • Extracellular matrix
    • Peptide
    • Supramolecule
    • Triple helix

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Agricultural and Biological Sciences (miscellaneous)

    Cite this

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    abstract = "Collagens, characterized by a unique triple-helical structure, are the predominant component of extracellular matrices (ECMs) existing in all multicellular animals. Collagens not only maintain structural integrity of tissues and organs, but also regulate a number of biological events, including cell attachment, migration and differentiation, tissue regeneration and animal development. The specific functions of collagens are generally triggered by specific interactions of collagen-binding molecules (membrane receptors, soluble factors and other ECM components) with certain structures displayed on the collagen triple helices. Thus, synthetic triple-helical peptides that mimic the structure of native collagens have been used to investigate the individual collagen-protein interactions, as well as collagen structure and stability. The first part of this article illustrates the design of various collagen-mimetic peptides and their recent applications in matrix biology. Collagen is also acknowledged as one of the most promising biomaterials in regenerative medicine and tissue engineering. However, the use of animal-derived collagens in human could put the recipients at risks of pathogen transmission or allergic reactions. Hence, the production of safe artificial collagen surrogates is currently of considerable interest. The latter part of this article reviews recent attempts to develop artificial collagens as novel biomaterials.",
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