Detection and characterization of new mangromicin analogs by tandem mass spectrometry

Yoshiyuki Kamiya, Takuji Nakashima, Takako Taniguchi, Yōko Takahashi, Satoshi Ōmura, Hisaaki Taniguchi

Research output: Contribution to journalArticlepeer-review


Many useful natural products are usually screened based on their biological activities. On the other hand, various natural products can be detected based on their physicochemical properties. We have already reported the isolation and characterization of mangromicins from a cultural broth of Lechevalieria aerocolonigenes K10-0216 using physicochemical screening. In this report, we have conducted the mass spectrometry-based screening of new mangromicin analogs based on the neutral loss pattern originated from the unique cyclopentadecane skeleton of mangromicins. Two novel analogs were detected showing characteristic neutral loss pattern found in eight known mangromicin analogs. We propose the structures of the newly-found analogs based on the mass spectrometric as well as genomic and metabolic pathway data.

Original languageEnglish
Pages (from-to)1605-1614
Number of pages10
JournalBioscience, biotechnology, and biochemistry
Issue number12
Publication statusPublished - 2022 Nov 23


  • Lechevalieria aerocolonigenes
  • mass spectrometry
  • neutral loss
  • new mangromicin analogs
  • physicochemical screening

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


Dive into the research topics of 'Detection and characterization of new mangromicin analogs by tandem mass spectrometry'. Together they form a unique fingerprint.

Cite this