Detection of atypical network development patterns in children with autism spectrum disorder using magnetoencephalography

Fang Duan, Katsumi Watanabe, Yuko Yoshimura, Mitsuru Kikuchi, Yoshio Minabe, Kazuyuki Aihara

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Autism spectrum disorder (ASD) is a developmental disorder that involves developmental delays. It has been hypothesized that aberrant neural connectivity in ASD may cause atypical brain network development. Brain graphs not only describe the differences in brain networks between clinical and control groups, but also provide information about network development within each group. In the present study, graph indices of brain networks were estimated in children with ASD and in typically developing (TD) children using magnetoencephalography performed while the children viewed a cartoon video. We examined brain graphs from a developmental point of view, and compared the networks between children with ASD and TD children. Network development patterns (NDPs) were assessed by examining the association between the graph indices and the raw scores on the achievement scale or the age of the children. The ASD and TD groups exhibited different NDPs at both network and nodal levels. In the left frontal areas, the nodal degree and efficiency of the ASD group were negatively correlated with the achievement scores. Reduced network connections were observed in the temporal and posterior areas of TD children. These results suggested that the atypical network developmental trajectory in children with ASD is associated with the development score rather than age.

    Original languageEnglish
    Article numbere0184422
    JournalPLoS One
    Volume12
    Issue number9
    DOIs
    Publication statusPublished - 2017 Sep 1

    Fingerprint

    Magnetoencephalography
    Brain
    brain
    Cartoons
    information networks
    Developmental Disabilities
    Information Services
    Trajectories
    Autism Spectrum Disorder
    magnetoencephalography
    autism
    trajectories
    Efficiency
    Control Groups

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)

    Cite this

    Detection of atypical network development patterns in children with autism spectrum disorder using magnetoencephalography. / Duan, Fang; Watanabe, Katsumi; Yoshimura, Yuko; Kikuchi, Mitsuru; Minabe, Yoshio; Aihara, Kazuyuki.

    In: PLoS One, Vol. 12, No. 9, e0184422, 01.09.2017.

    Research output: Contribution to journalArticle

    Duan, Fang ; Watanabe, Katsumi ; Yoshimura, Yuko ; Kikuchi, Mitsuru ; Minabe, Yoshio ; Aihara, Kazuyuki. / Detection of atypical network development patterns in children with autism spectrum disorder using magnetoencephalography. In: PLoS One. 2017 ; Vol. 12, No. 9.
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