Detection of cardiac biomarkers exploiting Surface Enhanced Raman Scattering (SERS) using a nanofluidic channel based biosensor towards coronary point-of-care diagnostics

Melodie E. Benford, Miao Wang, Jun Kameoka, Gerard L. Coté

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

According to the World Health Organization, cardiovascular disease is the most common cause of death in the world. In the US, over 115 million people visit the emergency department (ED), 5 million of which may have acute coronary syndrome (ACS). Cardiac biomarkers can provide early identification and diagnosis of ACS, and can provide information on the prognosis of the patient by assessing the risk of death. In addition, the biomarkers can serve as criteria for admission, indicate possibility of re-infarction, or eliminate ACS as a diagnosis altogether. We propose a SERSbased multi-marker approach towards a point-of-care diagnostic system for ACS. Using a nanofluidic device consisting of a microchannel leading into a nanochannel, we formed SERS active sites by mechanically aggregating gold particles (60 nm) at the entrance to the nanochannel (40 nmx1 ìm). The induced capillary flow produces a high density of aggregated nanoparticles at this precise region, creating areas with enhancedelectromagnetic fields within the aggregates, shifting the plasmon resonance to the near infrared region, in resonance with incident laser wavelength. With this robust sensing platform, we were able to obtain qualitative information of brain natriuretic peptide (biomarker of ventricular dysfunction or pulmonary stress), troponin I (biomarker of myocardial necrosis), and C-reactive protein (biomarker of inflammation potentially caused by atherosclerosis).

Original languageEnglish
Title of host publicationPlasmonics in Biology and Medicine VI
DOIs
Publication statusPublished - 2009
Externally publishedYes
EventPlasmonics in Biology and Medicine VI - San Jose, CA, United States
Duration: 2009 Jan 262009 Jan 27

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7192
ISSN (Print)1605-7422

Conference

ConferencePlasmonics in Biology and Medicine VI
Country/TerritoryUnited States
CitySan Jose, CA
Period09/1/2609/1/27

Keywords

  • Cardiac biomarker
  • Colloidal gold
  • Nanochannel
  • Nanofluidic device
  • Point-of-care diagnostics
  • Raman spectroscopy
  • SERS
  • Surface enhanced

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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