Detection of matrix metalloproteinase-2 by field effect transistor with a fibronectin-immobilized gate

Daisuke Yamamoto, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Matrix metalloproteinase (MMP) is known to be involved in chronic inflammation, tumor invasion, and carcinogenesis. To detect MMP-2, we examined the use of field effect transistors (FETs). After the addition of MMP-2 to a fibronectin (FN)- immobilized gate, negative value of FET response was observed, which indicates MMP-2 decreased the amount of negative charges arising from FN molecules. This FET device successfully detected MMP-2 by utilizing degradation of FN on the gate.

Original languageEnglish
Pages (from-to)825-827
Number of pages3
JournalChemistry Letters
Volume41
Issue number8
DOIs
Publication statusPublished - 2012

Fingerprint

Matrix Metalloproteinase 2
Field effect transistors
Fibronectins
Matrix Metalloproteinases
Tumors
Degradation
Molecules

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Detection of matrix metalloproteinase-2 by field effect transistor with a fibronectin-immobilized gate. / Yamamoto, Daisuke; Hideshima, Sho; Kuroiwa, Shigeki; Nakanishi, Takuya; Osaka, Tetsuya.

In: Chemistry Letters, Vol. 41, No. 8, 2012, p. 825-827.

Research output: Contribution to journalArticle

@article{11df5a89bd534b7b841b6122402f09c7,
title = "Detection of matrix metalloproteinase-2 by field effect transistor with a fibronectin-immobilized gate",
abstract = "Matrix metalloproteinase (MMP) is known to be involved in chronic inflammation, tumor invasion, and carcinogenesis. To detect MMP-2, we examined the use of field effect transistors (FETs). After the addition of MMP-2 to a fibronectin (FN)- immobilized gate, negative value of FET response was observed, which indicates MMP-2 decreased the amount of negative charges arising from FN molecules. This FET device successfully detected MMP-2 by utilizing degradation of FN on the gate.",
author = "Daisuke Yamamoto and Sho Hideshima and Shigeki Kuroiwa and Takuya Nakanishi and Tetsuya Osaka",
year = "2012",
doi = "10.1246/cl.2012.825",
language = "English",
volume = "41",
pages = "825--827",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "8",

}

TY - JOUR

T1 - Detection of matrix metalloproteinase-2 by field effect transistor with a fibronectin-immobilized gate

AU - Yamamoto, Daisuke

AU - Hideshima, Sho

AU - Kuroiwa, Shigeki

AU - Nakanishi, Takuya

AU - Osaka, Tetsuya

PY - 2012

Y1 - 2012

N2 - Matrix metalloproteinase (MMP) is known to be involved in chronic inflammation, tumor invasion, and carcinogenesis. To detect MMP-2, we examined the use of field effect transistors (FETs). After the addition of MMP-2 to a fibronectin (FN)- immobilized gate, negative value of FET response was observed, which indicates MMP-2 decreased the amount of negative charges arising from FN molecules. This FET device successfully detected MMP-2 by utilizing degradation of FN on the gate.

AB - Matrix metalloproteinase (MMP) is known to be involved in chronic inflammation, tumor invasion, and carcinogenesis. To detect MMP-2, we examined the use of field effect transistors (FETs). After the addition of MMP-2 to a fibronectin (FN)- immobilized gate, negative value of FET response was observed, which indicates MMP-2 decreased the amount of negative charges arising from FN molecules. This FET device successfully detected MMP-2 by utilizing degradation of FN on the gate.

UR - http://www.scopus.com/inward/record.url?scp=84865300743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865300743&partnerID=8YFLogxK

U2 - 10.1246/cl.2012.825

DO - 10.1246/cl.2012.825

M3 - Article

AN - SCOPUS:84865300743

VL - 41

SP - 825

EP - 827

JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 8

ER -