Detection of matrix metalloproteinase-2 by field effect transistor with a fibronectin-immobilized gate

Daisuke Yamamoto, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Matrix metalloproteinase (MMP) is known to be involved in chronic inflammation, tumor invasion, and carcinogenesis. To detect MMP-2, we examined the use of field effect transistors (FETs). After the addition of MMP-2 to a fibronectin (FN)- immobilized gate, negative value of FET response was observed, which indicates MMP-2 decreased the amount of negative charges arising from FN molecules. This FET device successfully detected MMP-2 by utilizing degradation of FN on the gate.

Original languageEnglish
Pages (from-to)825-827
Number of pages3
JournalChemistry Letters
Volume41
Issue number8
DOIs
Publication statusPublished - 2012 Aug 28

ASJC Scopus subject areas

  • Chemistry(all)

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