Detection of protein binding by shear mode ultrasonic reflection coefficients using c-axis tilted ScAlN film above 100MHz

Yamashita Miho, Takahiko Yanagitani

Research output: Contribution to journalConference articlepeer-review

Abstract

QCM (quartz crystal microbalance) is suitable for biomolecules sensing since AT-cut quartz operates in shear mode. However, it is not clear that whether the decrease of resonant frequency due to protein-binding on the on the resonator surface is caused by mass loading or viscoelastic change near the surface. The ultrasonic reflectometry is one of the ways to determine viscoelastic properties of liquids such as the complex acoustic impedance, the shear modulus, and the shear viscosity. These properties can be determined from the shear wave complex reflection coefficient at the solid - liquid boundary. In this study, we investigated the shear wave reflection change due to biotin-streptavidin interaction using quasi shear mode c-axis tilted ScAlN thin film. As a result, the change of amplitude and phase of shear reflection coefficient were qualitatively observed when 200g/ml streptavidin were introduced to the biotin-coated self-assembled monolayers (SAMs) on the reflection boundary.

Original languageEnglish
JournalIEEE International Ultrasonics Symposium, IUS
DOIs
Publication statusPublished - 2021
Event2021 IEEE International Ultrasonics Symposium, IUS 2021 - Virtual, Online, China
Duration: 2011 Sep 112011 Sep 16

Keywords

  • ScAlN
  • biomolecular interaction
  • biotin
  • piezoelectric film
  • shear mode ultrasonic
  • ultrasonic reflectometry

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Fingerprint

Dive into the research topics of 'Detection of protein binding by shear mode ultrasonic reflection coefficients using c-axis tilted ScAlN film above 100MHz'. Together they form a unique fingerprint.

Cite this