Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

Ryo Masuda, Risa Hayashi, Hiroshi Nose, Akihiro Taguchi, Yoshio Hayashi, Hiroyuki Yasui, Takaki Koide

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Aim: The development of a platinum anticancer agent that has improved efficacy by efficient delivery to a tumor and that suppresses side effects has been investigated. Arginine-rich triple-helical peptides are promising drug carriers because of their stability in body fluids and cell-penetrating activity. Results: We synthesized a carboplatin derivative conjugated with an arginine-rich triple-helical peptide. This derivative released platinum under acidic conditions or in the presence Cl- ions. Administration of this derivative to P388 tumor-bearing mice showed comparable survival rates to twice the dose of carboplatin, which was attributed to a longer mean residence time by pharmacokinetics analysis. Conclusion: The collagen-like triple-helical peptide was an efficient carrier of a platinum anticancer agent because of a modification to its pharmacokinetic profile.

    Original languageEnglish
    Pages (from-to)619-629
    Number of pages11
    JournalFuture Medicinal Chemistry
    Volume10
    Issue number6
    DOIs
    Publication statusPublished - 2018 Mar 1

    Fingerprint

    Carboplatin
    Platinum
    Collagen
    Antineoplastic Agents
    Peptides
    Arginine
    Pharmacokinetics
    Drug Carriers
    Body Fluids
    Neoplasms
    Ions

    Keywords

    • antitumor agent
    • pharmacokinetics
    • triple-helical peptide

    ASJC Scopus subject areas

    • Molecular Medicine
    • Pharmacology
    • Drug Discovery

    Cite this

    Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide. / Masuda, Ryo; Hayashi, Risa; Nose, Hiroshi; Taguchi, Akihiro; Hayashi, Yoshio; Yasui, Hiroyuki; Koide, Takaki.

    In: Future Medicinal Chemistry, Vol. 10, No. 6, 01.03.2018, p. 619-629.

    Research output: Contribution to journalArticle

    Masuda, Ryo ; Hayashi, Risa ; Nose, Hiroshi ; Taguchi, Akihiro ; Hayashi, Yoshio ; Yasui, Hiroyuki ; Koide, Takaki. / Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide. In: Future Medicinal Chemistry. 2018 ; Vol. 10, No. 6. pp. 619-629.
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    AU - Hayashi, Risa

    AU - Nose, Hiroshi

    AU - Taguchi, Akihiro

    AU - Hayashi, Yoshio

    AU - Yasui, Hiroyuki

    AU - Koide, Takaki

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