Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

Ryo Masuda, Risa Hayashi, Hiroshi Nose, Akihiro Taguchi, Yoshio Hayashi, Hiroyuki Yasui, Takaki Koide

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Aim: The development of a platinum anticancer agent that has improved efficacy by efficient delivery to a tumor and that suppresses side effects has been investigated. Arginine-rich triple-helical peptides are promising drug carriers because of their stability in body fluids and cell-penetrating activity. Results: We synthesized a carboplatin derivative conjugated with an arginine-rich triple-helical peptide. This derivative released platinum under acidic conditions or in the presence Cl- ions. Administration of this derivative to P388 tumor-bearing mice showed comparable survival rates to twice the dose of carboplatin, which was attributed to a longer mean residence time by pharmacokinetics analysis. Conclusion: The collagen-like triple-helical peptide was an efficient carrier of a platinum anticancer agent because of a modification to its pharmacokinetic profile.

    Original languageEnglish
    Pages (from-to)619-629
    Number of pages11
    JournalFuture Medicinal Chemistry
    Volume10
    Issue number6
    DOIs
    Publication statusPublished - 2018 Mar 1

    Keywords

    • antitumor agent
    • pharmacokinetics
    • triple-helical peptide

    ASJC Scopus subject areas

    • Molecular Medicine
    • Pharmacology
    • Drug Discovery

    Fingerprint Dive into the research topics of 'Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide'. Together they form a unique fingerprint.

  • Cite this