Development of a compact scintillator-based high-resolution Compton camera for molecular imaging

A. Kishimoto, Jun Kataoka, A. Koide, K. Sueoka, Y. Iwamoto, T. Taya, S. Ohsuka

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    The Compton camera, which shows gamma-ray distribution utilizing the kinematics of Compton scattering, is a promising detector capable of imaging across a wide range of energy. In this study, we aim to construct a small-animal molecular imaging system in a wide energy range by using the Compton camera. We developed a compact medical Compton camera based on a Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) scintillator and multi-pixel photon counter (MPPC). A basic performance confirmed that for 662keV, the typical energy resolution was 7.4% (FWHM) and the angular resolution was 4.5° (FWHM). We then used the medical Compton camera to conduct imaging experiments based on a 3-D imaging reconstruction algorithm using the multi-angle data acquisition method. The result confirmed that for a 137Cs point source at a distance of 4cm, the image had a spatial resolution of 3.1mm (FWHM). Furthermore, we succeeded in producing 3-D multi-color image of different simultaneous energy sources (22Na [511keV], 137Cs [662keV], and 54Mn [834keV]).

    Fingerprint

    Molecular imaging
    Phosphors
    scintillation counters
    Full width at half maximum
    Cameras
    cameras
    high resolution
    Imaging techniques
    Compton scattering
    energy sources
    angular resolution
    Gamma rays
    Imaging systems
    point sources
    data acquisition
    animals
    energy
    Data acquisition
    Kinematics
    counters

    Keywords

    • Compton camera
    • Depth of interaction

    ASJC Scopus subject areas

    • Instrumentation
    • Nuclear and High Energy Physics

    Cite this

    @article{bae07f93fbde4d259ba38f0adf5b3b3b,
    title = "Development of a compact scintillator-based high-resolution Compton camera for molecular imaging",
    abstract = "The Compton camera, which shows gamma-ray distribution utilizing the kinematics of Compton scattering, is a promising detector capable of imaging across a wide range of energy. In this study, we aim to construct a small-animal molecular imaging system in a wide energy range by using the Compton camera. We developed a compact medical Compton camera based on a Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) scintillator and multi-pixel photon counter (MPPC). A basic performance confirmed that for 662keV, the typical energy resolution was 7.4{\%} (FWHM) and the angular resolution was 4.5° (FWHM). We then used the medical Compton camera to conduct imaging experiments based on a 3-D imaging reconstruction algorithm using the multi-angle data acquisition method. The result confirmed that for a 137Cs point source at a distance of 4cm, the image had a spatial resolution of 3.1mm (FWHM). Furthermore, we succeeded in producing 3-D multi-color image of different simultaneous energy sources (22Na [511keV], 137Cs [662keV], and 54Mn [834keV]).",
    keywords = "Compton camera, Depth of interaction",
    author = "A. Kishimoto and Jun Kataoka and A. Koide and K. Sueoka and Y. Iwamoto and T. Taya and S. Ohsuka",
    year = "2016",
    month = "3",
    day = "7",
    doi = "10.1016/j.nima.2016.06.056",
    language = "English",
    journal = "Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",
    issn = "0168-9002",
    publisher = "Elsevier",

    }

    TY - JOUR

    T1 - Development of a compact scintillator-based high-resolution Compton camera for molecular imaging

    AU - Kishimoto, A.

    AU - Kataoka, Jun

    AU - Koide, A.

    AU - Sueoka, K.

    AU - Iwamoto, Y.

    AU - Taya, T.

    AU - Ohsuka, S.

    PY - 2016/3/7

    Y1 - 2016/3/7

    N2 - The Compton camera, which shows gamma-ray distribution utilizing the kinematics of Compton scattering, is a promising detector capable of imaging across a wide range of energy. In this study, we aim to construct a small-animal molecular imaging system in a wide energy range by using the Compton camera. We developed a compact medical Compton camera based on a Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) scintillator and multi-pixel photon counter (MPPC). A basic performance confirmed that for 662keV, the typical energy resolution was 7.4% (FWHM) and the angular resolution was 4.5° (FWHM). We then used the medical Compton camera to conduct imaging experiments based on a 3-D imaging reconstruction algorithm using the multi-angle data acquisition method. The result confirmed that for a 137Cs point source at a distance of 4cm, the image had a spatial resolution of 3.1mm (FWHM). Furthermore, we succeeded in producing 3-D multi-color image of different simultaneous energy sources (22Na [511keV], 137Cs [662keV], and 54Mn [834keV]).

    AB - The Compton camera, which shows gamma-ray distribution utilizing the kinematics of Compton scattering, is a promising detector capable of imaging across a wide range of energy. In this study, we aim to construct a small-animal molecular imaging system in a wide energy range by using the Compton camera. We developed a compact medical Compton camera based on a Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) scintillator and multi-pixel photon counter (MPPC). A basic performance confirmed that for 662keV, the typical energy resolution was 7.4% (FWHM) and the angular resolution was 4.5° (FWHM). We then used the medical Compton camera to conduct imaging experiments based on a 3-D imaging reconstruction algorithm using the multi-angle data acquisition method. The result confirmed that for a 137Cs point source at a distance of 4cm, the image had a spatial resolution of 3.1mm (FWHM). Furthermore, we succeeded in producing 3-D multi-color image of different simultaneous energy sources (22Na [511keV], 137Cs [662keV], and 54Mn [834keV]).

    KW - Compton camera

    KW - Depth of interaction

    UR - http://www.scopus.com/inward/record.url?scp=84977581067&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84977581067&partnerID=8YFLogxK

    U2 - 10.1016/j.nima.2016.06.056

    DO - 10.1016/j.nima.2016.06.056

    M3 - Article

    JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

    JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

    SN - 0168-9002

    ER -