Development of a fetal circadian rhythm after disruption of the maternal circadian system

Shigenobu Shibata, Robert Y. Moore

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The role of maternal circadian rhythms in the development of the fetal circadian system was investigated in the rat. Pregnant females were subjected to procedures known to disrupt circadian function, ablation of the maternal suprachiasmatic nuclei (SCN) or housing in constant illumination, on gestational day 10. Circadian function was assessed in fetuses at gestational day 22 by analysis of glucose utilization in hypothalamic slices in vitro using the 2-deoxyglucose method. Fetuses from control females exhibit a robust rhythm in glucose utilization in the SCN. In contrast, the SCN of fetuses from females with SCN lesions, or housed in constant illumination, show no significant day-night difference in glucose utilization. Analysis of individual brains indicates, however, that this apparent disruption in the development of circadian rhythmicity in metabolism in the fetal SCN is due to a desynchronization of individual fetuses resulting from the loss of maternal entraining influences. Thus, the fetal SCN is capable of developing a circadian rhythm in glucose utilization independent of the maternal circadian system.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalDevelopmental Brain Research
Volume41
Issue number1-2
DOIs
Publication statusPublished - 1988 Jun 1
Externally publishedYes

Fingerprint

Suprachiasmatic Nucleus
Fetal Development
Circadian Rhythm
Mothers
Fetus
Glucose
Lighting
Deoxyglucose
Periodicity
Brain

Keywords

  • 2-Deoxyglucose method
  • Circadian rhythm
  • Development
  • Maternal influence
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Development of a fetal circadian rhythm after disruption of the maternal circadian system. / Shibata, Shigenobu; Moore, Robert Y.

In: Developmental Brain Research, Vol. 41, No. 1-2, 01.06.1988, p. 313-317.

Research output: Contribution to journalArticle

@article{95f624f951c54b3eb2394dcfe5598f9c,
title = "Development of a fetal circadian rhythm after disruption of the maternal circadian system",
abstract = "The role of maternal circadian rhythms in the development of the fetal circadian system was investigated in the rat. Pregnant females were subjected to procedures known to disrupt circadian function, ablation of the maternal suprachiasmatic nuclei (SCN) or housing in constant illumination, on gestational day 10. Circadian function was assessed in fetuses at gestational day 22 by analysis of glucose utilization in hypothalamic slices in vitro using the 2-deoxyglucose method. Fetuses from control females exhibit a robust rhythm in glucose utilization in the SCN. In contrast, the SCN of fetuses from females with SCN lesions, or housed in constant illumination, show no significant day-night difference in glucose utilization. Analysis of individual brains indicates, however, that this apparent disruption in the development of circadian rhythmicity in metabolism in the fetal SCN is due to a desynchronization of individual fetuses resulting from the loss of maternal entraining influences. Thus, the fetal SCN is capable of developing a circadian rhythm in glucose utilization independent of the maternal circadian system.",
keywords = "2-Deoxyglucose method, Circadian rhythm, Development, Maternal influence, Suprachiasmatic nucleus",
author = "Shigenobu Shibata and Moore, {Robert Y.}",
year = "1988",
month = "6",
day = "1",
doi = "10.1016/0165-3806(88)90194-0",
language = "English",
volume = "41",
pages = "313--317",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "1-2",

}

TY - JOUR

T1 - Development of a fetal circadian rhythm after disruption of the maternal circadian system

AU - Shibata, Shigenobu

AU - Moore, Robert Y.

PY - 1988/6/1

Y1 - 1988/6/1

N2 - The role of maternal circadian rhythms in the development of the fetal circadian system was investigated in the rat. Pregnant females were subjected to procedures known to disrupt circadian function, ablation of the maternal suprachiasmatic nuclei (SCN) or housing in constant illumination, on gestational day 10. Circadian function was assessed in fetuses at gestational day 22 by analysis of glucose utilization in hypothalamic slices in vitro using the 2-deoxyglucose method. Fetuses from control females exhibit a robust rhythm in glucose utilization in the SCN. In contrast, the SCN of fetuses from females with SCN lesions, or housed in constant illumination, show no significant day-night difference in glucose utilization. Analysis of individual brains indicates, however, that this apparent disruption in the development of circadian rhythmicity in metabolism in the fetal SCN is due to a desynchronization of individual fetuses resulting from the loss of maternal entraining influences. Thus, the fetal SCN is capable of developing a circadian rhythm in glucose utilization independent of the maternal circadian system.

AB - The role of maternal circadian rhythms in the development of the fetal circadian system was investigated in the rat. Pregnant females were subjected to procedures known to disrupt circadian function, ablation of the maternal suprachiasmatic nuclei (SCN) or housing in constant illumination, on gestational day 10. Circadian function was assessed in fetuses at gestational day 22 by analysis of glucose utilization in hypothalamic slices in vitro using the 2-deoxyglucose method. Fetuses from control females exhibit a robust rhythm in glucose utilization in the SCN. In contrast, the SCN of fetuses from females with SCN lesions, or housed in constant illumination, show no significant day-night difference in glucose utilization. Analysis of individual brains indicates, however, that this apparent disruption in the development of circadian rhythmicity in metabolism in the fetal SCN is due to a desynchronization of individual fetuses resulting from the loss of maternal entraining influences. Thus, the fetal SCN is capable of developing a circadian rhythm in glucose utilization independent of the maternal circadian system.

KW - 2-Deoxyglucose method

KW - Circadian rhythm

KW - Development

KW - Maternal influence

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0023929627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023929627&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(88)90194-0

DO - 10.1016/0165-3806(88)90194-0

M3 - Article

C2 - 3401806

AN - SCOPUS:0023929627

VL - 41

SP - 313

EP - 317

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 1-2

ER -