Development of a microdevice for cellular analysis integrated with microvalves

Masaki Kanai, Tatsuya Munaka, Hirohisa Abe, Hiroaki Nakanishi, Shuichi Shoji

    Research output: Contribution to journalArticle

    Abstract

    We have developed a microdevice for cellular analysis, which has a microwell for cell culture and on-chip microvalves for sample injection. In order to reduce dead volume in the sample injector, the device structure is designed to minimize distance between the microwell and the sample injector. Two types of PDMS are used for the lid of the microdevice and the diaphragm of the microvalves, which have an advantage of high transparency and that of bio-compatibility, respectively. Mechanical property and gas permeability of the two types of PDMS are examined and the results show that the both PDMS are applicable to the microdevice. Using the fabricated prototype device, sample injection of the order of nano-liter is demonstrated successfully.

    Original languageEnglish
    JournalIEEJ Transactions on Sensors and Micromachines
    Volume127
    Issue number2
    Publication statusPublished - 2007

    Fingerprint

    Gas permeability
    Diaphragms
    Biocompatibility
    Cell culture
    Transparency
    Mechanical properties

    Keywords

    • μ TAS
    • Cellular analysis
    • Drug screening
    • Microvalve
    • PDMS

    ASJC Scopus subject areas

    • Electrical and Electronic Engineering
    • Mechanical Engineering

    Cite this

    Development of a microdevice for cellular analysis integrated with microvalves. / Kanai, Masaki; Munaka, Tatsuya; Abe, Hirohisa; Nakanishi, Hiroaki; Shoji, Shuichi.

    In: IEEJ Transactions on Sensors and Micromachines, Vol. 127, No. 2, 2007.

    Research output: Contribution to journalArticle

    Kanai, Masaki ; Munaka, Tatsuya ; Abe, Hirohisa ; Nakanishi, Hiroaki ; Shoji, Shuichi. / Development of a microdevice for cellular analysis integrated with microvalves. In: IEEJ Transactions on Sensors and Micromachines. 2007 ; Vol. 127, No. 2.
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