Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution

Aya Kishimoto, Jun Kataoka, Takuya Kato, Takamasa Miura, Takeshi Nakamori, Kei Kamada, Shigeyuki Nakamura, Kenichi Sato, Yoshitaka Ishikawa, Kazuhisa Yamamura, Seiichi Yamamoto

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    We are proposing a novel design for a module with depth of interaction (DOI) capability for gamma rays by measuring the pulse-height ratio of double-sided Multi-Pixel Photon Counters (MPPCs) coupled at both ends of a scintillation crystal block. Thanks to newly developed monolithic MPPC arrays consisting of 4×4 channels with a three-side buttable package, the module is very thin and compact, thereby enabling less dead space between each module when arranged into a fully designed gantry. To demonstrate our concept of a DOI measuring technique, we first made a 1-D crystal array consisting of five Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) cubic crystals measuring 3×3×3 mm3 in size, separated by a layer of air. When the light signals output from both ends are read with the MPPCs, the position of each crystal is clearly distinguished with a spatial uncertainty of 0.48±0.03 mm. For 3-D measurements, we then fabricated three different type arrays: [A] 4×4×4 matrix of 3×3×3 mm3 pixels, [B] 5×5×5 matrix of 2×2×2 mm 3 pixels, and [C] 10×10×10 matrix of 1×1×1 mm3 pixels, with each pixel divided by a BaSO4 reflector in the 2-D direction and by a layer of air in the DOI direction. We demonstrated that the 3-D position of each Ce:GAGG pixel was clearly distinguished when illuminated by 662 keV gamma rays uniformly. Average energy resolutions of 9.8±0.8 %, 9.8±0.9 %, and 13.2±1.7 % were obtained for types A, B and C, respectively. These results suggest that our proposed method is simple and offers promise in achieving 1 mm 3-D spatial resolution for future medical imaging, particularly in positron emission tomography (PET).

    Original languageEnglish
    Title of host publicationIEEE Nuclear Science Symposium Conference Record
    Pages3128-3133
    Number of pages6
    DOIs
    Publication statusPublished - 2012
    Event2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 - Anaheim, CA
    Duration: 2012 Oct 292012 Nov 3

    Other

    Other2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012
    CityAnaheim, CA
    Period12/10/2912/11/3

    Fingerprint

    Photons
    Positron-Emission Tomography
    positrons
    counters
    tomography
    modules
    pixels
    Gamma Rays
    photons
    Air
    interactions
    Diagnostic Imaging
    Uncertainty
    crystals
    Light
    matrices
    gamma rays
    gantry cranes
    air
    pulse amplitude

    ASJC Scopus subject areas

    • Radiation
    • Nuclear and High Energy Physics
    • Radiology Nuclear Medicine and imaging

    Cite this

    Kishimoto, A., Kataoka, J., Kato, T., Miura, T., Nakamori, T., Kamada, K., ... Yamamoto, S. (2012). Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution. In IEEE Nuclear Science Symposium Conference Record (pp. 3128-3133). [6551714] https://doi.org/10.1109/NSSMIC.2012.6551714

    Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution. / Kishimoto, Aya; Kataoka, Jun; Kato, Takuya; Miura, Takamasa; Nakamori, Takeshi; Kamada, Kei; Nakamura, Shigeyuki; Sato, Kenichi; Ishikawa, Yoshitaka; Yamamura, Kazuhisa; Yamamoto, Seiichi.

    IEEE Nuclear Science Symposium Conference Record. 2012. p. 3128-3133 6551714.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Kishimoto, A, Kataoka, J, Kato, T, Miura, T, Nakamori, T, Kamada, K, Nakamura, S, Sato, K, Ishikawa, Y, Yamamura, K & Yamamoto, S 2012, Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution. in IEEE Nuclear Science Symposium Conference Record., 6551714, pp. 3128-3133, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012, Anaheim, CA, 12/10/29. https://doi.org/10.1109/NSSMIC.2012.6551714
    Kishimoto A, Kataoka J, Kato T, Miura T, Nakamori T, Kamada K et al. Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution. In IEEE Nuclear Science Symposium Conference Record. 2012. p. 3128-3133. 6551714 https://doi.org/10.1109/NSSMIC.2012.6551714
    Kishimoto, Aya ; Kataoka, Jun ; Kato, Takuya ; Miura, Takamasa ; Nakamori, Takeshi ; Kamada, Kei ; Nakamura, Shigeyuki ; Sato, Kenichi ; Ishikawa, Yoshitaka ; Yamamura, Kazuhisa ; Yamamoto, Seiichi. / Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution. IEEE Nuclear Science Symposium Conference Record. 2012. pp. 3128-3133
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    abstract = "We are proposing a novel design for a module with depth of interaction (DOI) capability for gamma rays by measuring the pulse-height ratio of double-sided Multi-Pixel Photon Counters (MPPCs) coupled at both ends of a scintillation crystal block. Thanks to newly developed monolithic MPPC arrays consisting of 4×4 channels with a three-side buttable package, the module is very thin and compact, thereby enabling less dead space between each module when arranged into a fully designed gantry. To demonstrate our concept of a DOI measuring technique, we first made a 1-D crystal array consisting of five Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) cubic crystals measuring 3×3×3 mm3 in size, separated by a layer of air. When the light signals output from both ends are read with the MPPCs, the position of each crystal is clearly distinguished with a spatial uncertainty of 0.48±0.03 mm. For 3-D measurements, we then fabricated three different type arrays: [A] 4×4×4 matrix of 3×3×3 mm3 pixels, [B] 5×5×5 matrix of 2×2×2 mm 3 pixels, and [C] 10×10×10 matrix of 1×1×1 mm3 pixels, with each pixel divided by a BaSO4 reflector in the 2-D direction and by a layer of air in the DOI direction. We demonstrated that the 3-D position of each Ce:GAGG pixel was clearly distinguished when illuminated by 662 keV gamma rays uniformly. Average energy resolutions of 9.8±0.8 {\%}, 9.8±0.9 {\%}, and 13.2±1.7 {\%} were obtained for types A, B and C, respectively. These results suggest that our proposed method is simple and offers promise in achieving 1 mm 3-D spatial resolution for future medical imaging, particularly in positron emission tomography (PET).",
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    AU - Nakamori, Takeshi

    AU - Kamada, Kei

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