Abstract
Ultra-thin polymer films (nanosheets) fabricated by a layer-by-layer (LbL) method possess unique properties such as high flexibility, adhesive strength, and transparency, and can be peeled off from a substrate and attached to various surfaces via a water-soluble supporting film. Therefore, flexible and transferrable LbL nanosheets are convenient tools as coating materials. Here, we fabricated a novel antimicrobial coating material by embedding silver nanoparticles (AgNPs) in an LbL nanosheet composed of layers of chitosan and sodium alginate (Ag-LbL nanosheet) by means of a photo-reduction method. Optimizing the amount of irradiated energy applied led to robust antimicrobial efficacy against methicillin-resistant Staphylococcus aureus (MRSA), sufficient to meet ISO standards (ISO 22196), while maintaining the flexibility and adhesive potency of the LbL nanosheet. Thus, the Ag-LbL nanosheet is a promising coating material that can provide antimicrobial efficacy to various surfaces.
| Original language | English |
|---|---|
| Pages (from-to) | 585-593 |
| Number of pages | 9 |
| Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Volume | 104 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 Apr 1 |
Keywords
- antimicrobial
- bacterial adherence
- coating
- in vitro
- polymer
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering