Development of an APD-based PET module and preliminary resolution performance of an experimental prototype gantry

Jun Kataoka, Hidenori Matsuda, Fumihiko Nishikido, Makoto Koizumi, Hirokazu Ikeda, Masao Yoshino, Takamasa Miura, Satoshi Tanaka, Yoshitaka Ishikawa, Nobuyuki Kawabata, Keiji Shimizu, Yusuke Matsunaga, Shunji Kishimoto, Hidetoshi Kubo, Yoshio Yanagida, Takeshi Nakamori

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The development of a high-resolution Positron Emission Tomography (PET) technique with sub-millimeter spatial resolution, which utilizes newly designed reverse-type APD-arrays, is uderway. All the detector blocks are modularized with the overall dimension of each module, including the APD array, LYSO scintillator matrix and Front-End Circuits (FECs), which are only 30 × 30 × 80mm3. Each APD device also has a monolithic 16 × 16 pixel structure with an active area of 1.0 mm2 per pixel. The FEC includes two identical analog ASICs specifically designed for APDs with a noise characteristic of 560+30 e-/pF and a timing resolution of 460 ps (rms), respectively. An energy resolution of 13.7 ± 1.1% (FWHM) with 662 keV gamma-rays was measured using the 16 × 16 arrays. At this stage a pair of module and coincidence circuits has been assembled into an experimental prototype gantry. Spatial resolutions of 0.9, 1.4, and 1.3 mm (FWHM) were obtained from FBP reconstructed images in preliminary experiments with a point source positioned centrally, and 1 and 5 mm off-center, respectively. Comparison with a Monte-Carlo simulation of a fully-designed gantry over a wider range of field-of-view showed good correlation with the experimental data. A simple but conceptual design of a DOI configuration is also proposed as a test example of a future APD-PET scanner.

    Original languageEnglish
    Article number5559465
    Pages (from-to)2448-2454
    Number of pages7
    JournalIEEE Transactions on Nuclear Science
    Volume57
    Issue number5 PART 1
    DOIs
    Publication statusPublished - 2010 Oct

    Fingerprint

    gantry cranes
    Positron emission tomography
    Full width at half maximum
    positrons
    Coincidence circuits
    tomography
    modules
    Pixels
    prototypes
    Networks (circuits)
    Application specific integrated circuits
    Conceptual design
    spatial resolution
    coincidence circuits
    pixels
    Gamma rays
    Phosphors
    application specific integrated circuits
    Detectors
    point sources

    Keywords

    • Avalanche photodiode
    • Depth-Of-Interaction (DOI)
    • image reconstruction
    • Positron Emission Tomography (PET)

    ASJC Scopus subject areas

    • Electrical and Electronic Engineering
    • Nuclear Energy and Engineering
    • Nuclear and High Energy Physics

    Cite this

    Development of an APD-based PET module and preliminary resolution performance of an experimental prototype gantry. / Kataoka, Jun; Matsuda, Hidenori; Nishikido, Fumihiko; Koizumi, Makoto; Ikeda, Hirokazu; Yoshino, Masao; Miura, Takamasa; Tanaka, Satoshi; Ishikawa, Yoshitaka; Kawabata, Nobuyuki; Shimizu, Keiji; Matsunaga, Yusuke; Kishimoto, Shunji; Kubo, Hidetoshi; Yanagida, Yoshio; Nakamori, Takeshi.

    In: IEEE Transactions on Nuclear Science, Vol. 57, No. 5 PART 1, 5559465, 10.2010, p. 2448-2454.

    Research output: Contribution to journalArticle

    Kataoka, J, Matsuda, H, Nishikido, F, Koizumi, M, Ikeda, H, Yoshino, M, Miura, T, Tanaka, S, Ishikawa, Y, Kawabata, N, Shimizu, K, Matsunaga, Y, Kishimoto, S, Kubo, H, Yanagida, Y & Nakamori, T 2010, 'Development of an APD-based PET module and preliminary resolution performance of an experimental prototype gantry', IEEE Transactions on Nuclear Science, vol. 57, no. 5 PART 1, 5559465, pp. 2448-2454. https://doi.org/10.1109/TNS.2010.2055889
    Kataoka, Jun ; Matsuda, Hidenori ; Nishikido, Fumihiko ; Koizumi, Makoto ; Ikeda, Hirokazu ; Yoshino, Masao ; Miura, Takamasa ; Tanaka, Satoshi ; Ishikawa, Yoshitaka ; Kawabata, Nobuyuki ; Shimizu, Keiji ; Matsunaga, Yusuke ; Kishimoto, Shunji ; Kubo, Hidetoshi ; Yanagida, Yoshio ; Nakamori, Takeshi. / Development of an APD-based PET module and preliminary resolution performance of an experimental prototype gantry. In: IEEE Transactions on Nuclear Science. 2010 ; Vol. 57, No. 5 PART 1. pp. 2448-2454.
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