Development of an implantable undulation type ventricular assist device for control of organ circulation

Tomoyuki Yambe, Yusuke Abe, Kou Imachi, Yasuyuki Shiraishi, Mune Ichi Shibata, Tasuku Yamaguchi, Quintian Wang, Xudong Duan, Hongjian Liu, Makoto Yoshizawa, Akira Tanaka, Hidetoshi Matsuki, Fumihiro Sato, You Ichi Haga, Masayoshi Esashi, Kouichi Tabayashi, Yoshinori Mitamura, Hiroshi Sasada, Mitsuo Umezu, Takehisa Matsuda & 1 others Shin Ichi Nitta

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    It is well known that a rotary blood pump (RP) is effective as a small ventricular assist device (VAD). It might be still more effective if pulsation was available. The undulation pump (UP), which is a type of small RP, can also produce pulsation. In Japan, a development project for an implantable type UP ventricular assist device (UPVAD) is now advanced. Six universities and some companies together have been in charge of the development project for 5 years. In this study, the influence which the UP under development has on circulation in internal organs was investigated. Goats with the same weight as an average Asian person were used for the experiment. The left chest cavity was opened after resection of the fourth rib and the heart was approached. A cannula was inserted in the left ventricle from the apex. An outflow cannula was inserted into the left descending aorta. Heart muscle was excised using a newly developed puncher. The UPVAD was implanted using a left-heart bypass system. The myocardial blood flow, carotid arterial blood flow, and the kidney blood flow were recorded together with an electrocardiogram, blood pressure, and the flow rate. In these animal experiments, the blood circulation dynamic state was stabilized and sufficient support of the left heart was observed. Myocardial blood flow, carotid arterial flow, and a kidney blood flow increase resulting from UPVAD support was observed. Often the problem of multiple organ failure is important at the time of clinical application of a ventricular assist device. Assisting circulation to internal organs is important for prevention of multiple organ failure. It was concluded that the UPVAD might be useful for prevention of multiple organ failure.

    Original languageEnglish
    Pages (from-to)940-944
    Number of pages5
    JournalArtificial Organs
    Volume28
    Issue number10
    DOIs
    Publication statusPublished - 2004 Oct

    Fingerprint

    Heart-Assist Devices
    Blood
    Pumps
    Multiple Organ Failure
    Left Heart Bypass
    Kidney
    Blood Circulation
    Blood pressure
    Hemodynamics
    Ribs
    Electrocardiography
    Thoracic Aorta
    Goats
    Heart Ventricles
    Muscle
    Myocardium
    Japan
    Animals
    Thorax
    Experiments

    Keywords

    • Laser doppler flowmeter
    • Multiple organ failure
    • Organ circulation
    • Undulation pump
    • Ventricular assist device

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Yambe, T., Abe, Y., Imachi, K., Shiraishi, Y., Shibata, M. I., Yamaguchi, T., ... Nitta, S. I. (2004). Development of an implantable undulation type ventricular assist device for control of organ circulation. Artificial Organs, 28(10), 940-944. https://doi.org/10.1111/j.1525-1594.2004.07382.x

    Development of an implantable undulation type ventricular assist device for control of organ circulation. / Yambe, Tomoyuki; Abe, Yusuke; Imachi, Kou; Shiraishi, Yasuyuki; Shibata, Mune Ichi; Yamaguchi, Tasuku; Wang, Quintian; Duan, Xudong; Liu, Hongjian; Yoshizawa, Makoto; Tanaka, Akira; Matsuki, Hidetoshi; Sato, Fumihiro; Haga, You Ichi; Esashi, Masayoshi; Tabayashi, Kouichi; Mitamura, Yoshinori; Sasada, Hiroshi; Umezu, Mitsuo; Matsuda, Takehisa; Nitta, Shin Ichi.

    In: Artificial Organs, Vol. 28, No. 10, 10.2004, p. 940-944.

    Research output: Contribution to journalArticle

    Yambe, T, Abe, Y, Imachi, K, Shiraishi, Y, Shibata, MI, Yamaguchi, T, Wang, Q, Duan, X, Liu, H, Yoshizawa, M, Tanaka, A, Matsuki, H, Sato, F, Haga, YI, Esashi, M, Tabayashi, K, Mitamura, Y, Sasada, H, Umezu, M, Matsuda, T & Nitta, SI 2004, 'Development of an implantable undulation type ventricular assist device for control of organ circulation', Artificial Organs, vol. 28, no. 10, pp. 940-944. https://doi.org/10.1111/j.1525-1594.2004.07382.x
    Yambe, Tomoyuki ; Abe, Yusuke ; Imachi, Kou ; Shiraishi, Yasuyuki ; Shibata, Mune Ichi ; Yamaguchi, Tasuku ; Wang, Quintian ; Duan, Xudong ; Liu, Hongjian ; Yoshizawa, Makoto ; Tanaka, Akira ; Matsuki, Hidetoshi ; Sato, Fumihiro ; Haga, You Ichi ; Esashi, Masayoshi ; Tabayashi, Kouichi ; Mitamura, Yoshinori ; Sasada, Hiroshi ; Umezu, Mitsuo ; Matsuda, Takehisa ; Nitta, Shin Ichi. / Development of an implantable undulation type ventricular assist device for control of organ circulation. In: Artificial Organs. 2004 ; Vol. 28, No. 10. pp. 940-944.
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