Development of an integrated system for rapid detection of biological agents

Hideyuki Terazono, Hiroyuki Takei, Masahito Hayashi, Akihiro Hattori, Kenji Yasuda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Weaponized biological agents are as great a threat as nuclear or chemical weapons. They must be detected at the earliest stage to prevent diffusion because once these agents are dispersed into the air, the rapidly decreasing concentration makes detection more of a challenge. Polymerase chain reaction (PCR) is a common method to create copies of a specific target region of a DNA sequence and to produce large quantities of DNA molecules. A few DNA molecules are rapidly amplified by PCR into billions of copies. While PCR is a powerful technique and is capable of countering new threats relatively easily, it is plagued by the number of processes necessary. Therefore, we have developed an integrated PCR system for rapid detection of biological agents captured from the air. Each processing function is performed by a dedicated module, and reduction in the process time has been made the top priority, without loss in the signal/noise ratio of the total system. Agents can be identified within 15 min from capture. A fully automated operation protects operators from exposure to potentially highly lethal samples.

Original languageEnglish
Title of host publicationChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI
DOIs
Publication statusPublished - 2010 Aug 27
EventChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI - Orlando, FL, United States
Duration: 2010 Apr 62010 Apr 8

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume7665
ISSN (Print)0277-786X

Other

OtherChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI
CountryUnited States
CityOrlando, FL
Period10/4/610/4/8

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Keywords

  • Biological agents
  • DNA
  • Integrated system
  • PCR
  • Polymerase Chain Reaction
  • bioterrorism
  • circulating water
  • heat-exchange
  • high speed
  • medical diagnostics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Terazono, H., Takei, H., Hayashi, M., Hattori, A., & Yasuda, K. (2010). Development of an integrated system for rapid detection of biological agents. In Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI [766503] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7665). https://doi.org/10.1117/12.849830