Development of an integrated system for rapid detection of biological agents

Hideyuki Terazono, Hiroyuki Takei, Masahito Hayashi, Akihiro Hattori, Kenji Yasuda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Weaponized biological agents are as great a threat as nuclear or chemical weapons. They must be detected at the earliest stage to prevent diffusion because once these agents are dispersed into the air, the rapidly decreasing concentration makes detection more of a challenge. Polymerase chain reaction (PCR) is a common method to create copies of a specific target region of a DNA sequence and to produce large quantities of DNA molecules. A few DNA molecules are rapidly amplified by PCR into billions of copies. While PCR is a powerful technique and is capable of countering new threats relatively easily, it is plagued by the number of processes necessary. Therefore, we have developed an integrated PCR system for rapid detection of biological agents captured from the air. Each processing function is performed by a dedicated module, and reduction in the process time has been made the top priority, without loss in the signal/noise ratio of the total system. Agents can be identified within 15 min from capture. A fully automated operation protects operators from exposure to potentially highly lethal samples.

Original languageEnglish
Title of host publicationChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI
Volume7665
DOIs
Publication statusPublished - 2010
Externally publishedYes
EventChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI - Orlando, FL, United States
Duration: 2010 Apr 62010 Apr 8

Other

OtherChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI
CountryUnited States
CityOrlando, FL
Period10/4/610/4/8

Fingerprint

polymerase chain reaction
Polymerase Chain Reaction
Polymerase chain reaction
Biological Factors
Integrated System
deoxyribonucleic acid
DNA
Molecules
nuclear weapons
weapons
DNA sequences
air
Air
DNA Sequence
molecules
modules
operators
Module
Target
Necessary

Keywords

  • Biological agents
  • bioterrorism
  • circulating water
  • DNA
  • heat-exchange
  • high speed
  • Integrated system
  • medical diagnostics
  • PCR
  • Polymerase Chain Reaction

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Terazono, H., Takei, H., Hayashi, M., Hattori, A., & Yasuda, K. (2010). Development of an integrated system for rapid detection of biological agents. In Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI (Vol. 7665). [766503] https://doi.org/10.1117/12.849830

Development of an integrated system for rapid detection of biological agents. / Terazono, Hideyuki; Takei, Hiroyuki; Hayashi, Masahito; Hattori, Akihiro; Yasuda, Kenji.

Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI. Vol. 7665 2010. 766503.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Terazono, H, Takei, H, Hayashi, M, Hattori, A & Yasuda, K 2010, Development of an integrated system for rapid detection of biological agents. in Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI. vol. 7665, 766503, Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI, Orlando, FL, United States, 10/4/6. https://doi.org/10.1117/12.849830
Terazono H, Takei H, Hayashi M, Hattori A, Yasuda K. Development of an integrated system for rapid detection of biological agents. In Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI. Vol. 7665. 2010. 766503 https://doi.org/10.1117/12.849830
Terazono, Hideyuki ; Takei, Hiroyuki ; Hayashi, Masahito ; Hattori, Akihiro ; Yasuda, Kenji. / Development of an integrated system for rapid detection of biological agents. Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI. Vol. 7665 2010.
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