Development of biodegradable nanosheets as nanoadhesive plaster

Shinji Takeoka, Yosuke Okamura, Toshinori Fujie, Yoshihito Fukui

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Sheet-shaped carriers having both obverse and reverse surfaces (thus, a large contact area for targeting a site and adhesive properties without any chemical cross-linker onto tissue surface) have several advantages as surgical dressings. These advantages include active targeting over spherically shaped carriers, which thus have an extremely small contact area for targeting sites. Here, we propose a novel methodology for preparation of a freestanding, ultra-thin, and biocompatible polymer nanosheet having heterosurfaces, fabricated through macromolecular assembly. In the context of biomedical applications, the targeted properties include injectable sheet-shaped drug carriers having precisely controlled size by exploiting micropatterned substrate, and giant polymer nanosheets composed of biocompatible polysaccharides. A huge aspect ratio, in excess of 106, is particularly applicable for novel surgical dressings. These biocompatible polymer nanosheets having heterosurfaces can thus be regarded as new biomaterials for minimally invasive treatment.

Original languageEnglish
Pages (from-to)2259-2271
Number of pages13
JournalPure and Applied Chemistry
Volume80
Issue number11
DOIs
Publication statusPublished - 2008 Dec 23

Keywords

  • Albumin
  • Biodegradable
  • Biomaterials
  • Latex beads
  • Layer-by-layer
  • Nanosheets
  • Polymers
  • Polysaccharides
  • Self-assembled monolayers
  • Surface modification

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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