Abstract
Sheet-shaped carriers having both obverse and reverse surfaces (thus, a large contact area for targeting a site and adhesive properties without any chemical cross-linker onto tissue surface) have several advantages as surgical dressings. These advantages include active targeting over spherically shaped carriers, which thus have an extremely small contact area for targeting sites. Here, we propose a novel methodology for preparation of a freestanding, ultra-thin, and biocompatible polymer nanosheet having heterosurfaces, fabricated through macromolecular assembly. In the context of biomedical applications, the targeted properties include injectable sheet-shaped drug carriers having precisely controlled size by exploiting micropatterned substrate, and giant polymer nanosheets composed of biocompatible polysaccharides. A huge aspect ratio, in excess of 106, is particularly applicable for novel surgical dressings. These biocompatible polymer nanosheets having heterosurfaces can thus be regarded as new biomaterials for minimally invasive treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 2259-2271 |
| Number of pages | 13 |
| Journal | Pure and Applied Chemistry |
| Volume | 80 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2008 |
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Keywords
- Albumin
- Biodegradable
- Biomaterials
- Latex beads
- Layer-by-layer
- Nanosheets
- Polymers
- Polysaccharides
- Self-assembled monolayers
- Surface modification
ASJC Scopus subject areas
- Chemical Engineering(all)
- Chemistry(all)
Cite this
Development of biodegradable nanosheets as nanoadhesive plaster. / Takeoka, Shinji; Okamura, Yosuke; Fujie, Toshinori; Fukui, Yoshihito.
In: Pure and Applied Chemistry, Vol. 80, No. 11, 2008, p. 2259-2271.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of biodegradable nanosheets as nanoadhesive plaster
AU - Takeoka, Shinji
AU - Okamura, Yosuke
AU - Fujie, Toshinori
AU - Fukui, Yoshihito
PY - 2008
Y1 - 2008
N2 - Sheet-shaped carriers having both obverse and reverse surfaces (thus, a large contact area for targeting a site and adhesive properties without any chemical cross-linker onto tissue surface) have several advantages as surgical dressings. These advantages include active targeting over spherically shaped carriers, which thus have an extremely small contact area for targeting sites. Here, we propose a novel methodology for preparation of a freestanding, ultra-thin, and biocompatible polymer nanosheet having heterosurfaces, fabricated through macromolecular assembly. In the context of biomedical applications, the targeted properties include injectable sheet-shaped drug carriers having precisely controlled size by exploiting micropatterned substrate, and giant polymer nanosheets composed of biocompatible polysaccharides. A huge aspect ratio, in excess of 106, is particularly applicable for novel surgical dressings. These biocompatible polymer nanosheets having heterosurfaces can thus be regarded as new biomaterials for minimally invasive treatment.
AB - Sheet-shaped carriers having both obverse and reverse surfaces (thus, a large contact area for targeting a site and adhesive properties without any chemical cross-linker onto tissue surface) have several advantages as surgical dressings. These advantages include active targeting over spherically shaped carriers, which thus have an extremely small contact area for targeting sites. Here, we propose a novel methodology for preparation of a freestanding, ultra-thin, and biocompatible polymer nanosheet having heterosurfaces, fabricated through macromolecular assembly. In the context of biomedical applications, the targeted properties include injectable sheet-shaped drug carriers having precisely controlled size by exploiting micropatterned substrate, and giant polymer nanosheets composed of biocompatible polysaccharides. A huge aspect ratio, in excess of 106, is particularly applicable for novel surgical dressings. These biocompatible polymer nanosheets having heterosurfaces can thus be regarded as new biomaterials for minimally invasive treatment.
KW - Albumin
KW - Biodegradable
KW - Biomaterials
KW - Latex beads
KW - Layer-by-layer
KW - Nanosheets
KW - Polymers
KW - Polysaccharides
KW - Self-assembled monolayers
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=57749111747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57749111747&partnerID=8YFLogxK
U2 - 10.1351/pac200880112259
DO - 10.1351/pac200880112259
M3 - Article
AN - SCOPUS:57749111747
VL - 80
SP - 2259
EP - 2271
JO - Pure and Applied Chemistry
JF - Pure and Applied Chemistry
SN - 0033-4545
IS - 11
ER -