Development of Chemical Substances Regulating Biofilm Formation

Akihiro Yamada, Hitomi Kitamura, Kaori Yamaguchi, Seketsu Fukuzawa, Chiyuki Kamijima, Kazunaga Yazawa, Makoto Kuramoto, Gui Yang Sheng Wang, Yasuyuki Fujitani, Daisuke Uemura

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The chemical substances which regulate biofilm formation were examined, and a bioassay system which uses marine bacteria with adhering properties was developed. This bioassay system is suitable for screening crude extracts from marine organisms. Using this system, those substances which regulate biofilm formation were isolated from marine organisms. For example, bis(deacetyl)solenolide D was obtained from the marine sponge Psammaplysilla purpurea. Novel nitroalkanes were also isolated from the Okinawan sponge Callyspongia sp. Ethyl N-(2-phenylethyl)carbamate isolated from the marine bacteria SCRC3P79 (Cytophaga sp.) inhibited biofilm formation. Furthermore, the N,N-dichloro, isocyanide, isothiocyanate, and dithiocarbamate derivatives of 2-(4-nitrophenyl)ethylamine, significantly inhibited the growth of marine attaching bacteria. Interestingly, most of the marine sponges examined contained anti-biofilm compounds, such as benzoic acid, aeroplysinin-I, and bromoageliferin.

Original languageEnglish
Pages (from-to)3061-3069
Number of pages9
JournalBulletin of the Chemical Society of Japan
Volume70
Issue number12
Publication statusPublished - 1997 Dec
Externally publishedYes

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Biofilms
Bacteria
Bioassay
Benzoic Acid
Carbamates
Cyanides
Complex Mixtures
Screening
Derivatives

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Yamada, A., Kitamura, H., Yamaguchi, K., Fukuzawa, S., Kamijima, C., Yazawa, K., ... Uemura, D. (1997). Development of Chemical Substances Regulating Biofilm Formation. Bulletin of the Chemical Society of Japan, 70(12), 3061-3069.

Development of Chemical Substances Regulating Biofilm Formation. / Yamada, Akihiro; Kitamura, Hitomi; Yamaguchi, Kaori; Fukuzawa, Seketsu; Kamijima, Chiyuki; Yazawa, Kazunaga; Kuramoto, Makoto; Wang, Gui Yang Sheng; Fujitani, Yasuyuki; Uemura, Daisuke.

In: Bulletin of the Chemical Society of Japan, Vol. 70, No. 12, 12.1997, p. 3061-3069.

Research output: Contribution to journalArticle

Yamada, A, Kitamura, H, Yamaguchi, K, Fukuzawa, S, Kamijima, C, Yazawa, K, Kuramoto, M, Wang, GYS, Fujitani, Y & Uemura, D 1997, 'Development of Chemical Substances Regulating Biofilm Formation', Bulletin of the Chemical Society of Japan, vol. 70, no. 12, pp. 3061-3069.
Yamada A, Kitamura H, Yamaguchi K, Fukuzawa S, Kamijima C, Yazawa K et al. Development of Chemical Substances Regulating Biofilm Formation. Bulletin of the Chemical Society of Japan. 1997 Dec;70(12):3061-3069.
Yamada, Akihiro ; Kitamura, Hitomi ; Yamaguchi, Kaori ; Fukuzawa, Seketsu ; Kamijima, Chiyuki ; Yazawa, Kazunaga ; Kuramoto, Makoto ; Wang, Gui Yang Sheng ; Fujitani, Yasuyuki ; Uemura, Daisuke. / Development of Chemical Substances Regulating Biofilm Formation. In: Bulletin of the Chemical Society of Japan. 1997 ; Vol. 70, No. 12. pp. 3061-3069.
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