Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

Shu Taira; Yong Zhong Du; Yuichi Hiratsuka; Kaoru Konishi; Tai Kubo; Taro Q.P. Uyeda; Noboru Yumoto; Masato Kodaka

Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

Shu Taira^*, Yong Zhong Du, Yuichi Hiratsuka, Kaoru Konishi, Tai Kubo, Taro Q.P. Uyeda, Noboru Yumoto, Masato Kodaka

^*Corresponding author for this work

Research output: Contribution to conference › Paper › peer-review

Abstract

We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.

Original language	English
Pages	2326
Number of pages	1
Publication status	Published - 2005
Externally published	Yes
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

DNA-conjugated microtubule
Motor protein
SNP analysis

ASJC Scopus subject areas

Engineering(all)

Cite this

@conference{a45e9b2343164089802f4c65877e1380,

title = "Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA",

abstract = "We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.",

keywords = "DNA-conjugated microtubule, Motor protein, SNP analysis",

author = "Shu Taira and Du, {Yong Zhong} and Yuichi Hiratsuka and Kaoru Konishi and Tai Kubo and Uyeda, {Taro Q.P.} and Noboru Yumoto and Masato Kodaka",

year = "2005",

language = "English",

pages = "2326",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

}

TY - CONF

T1 - Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

AU - Taira, Shu

AU - Du, Yong Zhong

AU - Hiratsuka, Yuichi

AU - Konishi, Kaoru

AU - Kubo, Tai

AU - Uyeda, Taro Q.P.

AU - Yumoto, Noboru

AU - Kodaka, Masato

PY - 2005

Y1 - 2005

N2 - We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.

AB - We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.

KW - DNA-conjugated microtubule

KW - Motor protein

KW - SNP analysis

UR - http://www.scopus.com/inward/record.url?scp=33645641440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645641440&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645641440

SP - 2326

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

Abstract

Conference

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this