Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

Shu Taira, Yong Zhong Du, Yuichi Hiratsuka, Kaoru Konishi, Tai Kubo, Taro Q.P. Uyeda, Noboru Yumoto, Masato Kodaka

Research output: Contribution to conferencePaper

Abstract

We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • DNA-conjugated microtubule
  • Motor protein
  • SNP analysis

ASJC Scopus subject areas

  • Engineering(all)

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    Taira, S., Du, Y. Z., Hiratsuka, Y., Konishi, K., Kubo, T., Uyeda, T. Q. P., Yumoto, N., & Kodaka, M. (2005). Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.