Development of mice biomagnetic measurement system using dc-SQUID magnetometer

Yumie Ono, Atsushi Ishiyama, Naoko Kasai, Akikazu Odawara

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    A biomagnetic measurement system on mice using a dc superconducting quantum interference device magnetometer has been developed. We are going to use it for comparative magnetoencephalogram (MEG) and magnetocardiogram (MCG) studies of transgenic mice to clarify the functional influence of gene modification in a living body. The system has a low-Tc direct coupled dc SQUID. A focuser type pickup coil whose outside/inside diameter is 1 mm/100 μm was adopted for detailed functional mapping of the brain or the heart of mice. The minimum lift-off distance was reduced to 700 μm to achieve the sufficient spatial resolution and magnetic field sensitivity. The field sensitivity of this system is 1.3 PT/Hz1/2 in the white-noise region (10 Hz-10 kHz). The MCG of a wild mouse at 9-months of age was measured and compared with the data of 3-month old mice. The spatial and time changes of MCG signals were similar in both ages of mice, while the amplitude of MCG signals of 9-month mice was less than 40% of that of 3-month mice. This decrease in MCG amplitude may be due to aging. The result suggested the capability of our system in evaluating the mice MCG signals.

    Original languageEnglish
    Pages (from-to)640-643
    Number of pages4
    JournalIEEE Transactions on Applied Superconductivity
    Volume15
    Issue number2 PART I
    DOIs
    Publication statusPublished - 2005 Jun

    Fingerprint

    SQUIDs
    Magnetometers
    magnetometers
    mice
    Pickups
    White noise
    Brain
    Genes
    Aging of materials
    Magnetic fields
    white noise
    genes
    brain
    coils
    spatial resolution
    interference
    sensors

    Keywords

    • Biomagnetics
    • Magneto-encephalography
    • Magnetocardiography
    • Mice
    • SQUID magnetometers

    ASJC Scopus subject areas

    • Electrical and Electronic Engineering
    • Physics and Astronomy (miscellaneous)

    Cite this

    Development of mice biomagnetic measurement system using dc-SQUID magnetometer. / Ono, Yumie; Ishiyama, Atsushi; Kasai, Naoko; Odawara, Akikazu.

    In: IEEE Transactions on Applied Superconductivity, Vol. 15, No. 2 PART I, 06.2005, p. 640-643.

    Research output: Contribution to journalArticle

    Ono, Yumie ; Ishiyama, Atsushi ; Kasai, Naoko ; Odawara, Akikazu. / Development of mice biomagnetic measurement system using dc-SQUID magnetometer. In: IEEE Transactions on Applied Superconductivity. 2005 ; Vol. 15, No. 2 PART I. pp. 640-643.
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