Development of polymer nanosheets inspired by extracellular matrix towards tissue engineering applications

Toshinori Fujie

Research output: Contribution to journalArticle

Abstract

Along with the development of regenerative medicine represented by stem cell engineering, tissue engineering is expected to be a promising technology for the replacement or treatment of diseased tissues and organs. Conventional cell transplantation has been achieved by harvesting autologous cells derived from the patients or stem cells. However, considering the long term process of cell culture in a sterile environment, it is crucial to develop new biomaterials that enhance the regeneration of damaged tissue by directing cellular organization. To this end, the authors focused on structure and function of extracellular matrix (ECM) at subcellular scale (tens to hundreds of nanometers), and envisioned to recapitulate the microstructure of ECM on a polymeric ultrathin film (nanosheet). In this paper, I introduce the fabrication and functionalization of nanosheets by integrating self-assembly of biomacromolecules and microfabrication techniques towards tissue engineering and regenerative medicine.

Original languageEnglish
Pages (from-to)408-417
Number of pages10
JournalKobunshi Ronbunshu
Volume71
Issue number9
Publication statusPublished - 2014 Sep 1

Fingerprint

Nanosheets
Stem cells
Tissue engineering
Polymers
polymer
Cell engineering
Tissue
engineering
matrix
Ultrathin films
Microfabrication
Biocompatible Materials
Cell culture
Polymer films
Biomaterials
medicine
Self assembly
Fabrication
Microstructure
transplantation

Keywords

  • Basement membrane
  • Extracellular matrix
  • Microfabrication
  • Nanosheets
  • Tissue engineering

ASJC Scopus subject areas

  • Polymers and Plastics
  • Environmental Science(all)
  • Materials Science (miscellaneous)
  • Chemical Engineering (miscellaneous)

Cite this

Development of polymer nanosheets inspired by extracellular matrix towards tissue engineering applications. / Fujie, Toshinori.

In: Kobunshi Ronbunshu, Vol. 71, No. 9, 01.09.2014, p. 408-417.

Research output: Contribution to journalArticle

@article{55ed4bfbcb914dabb9d04c0cab18c3b9,
title = "Development of polymer nanosheets inspired by extracellular matrix towards tissue engineering applications",
abstract = "Along with the development of regenerative medicine represented by stem cell engineering, tissue engineering is expected to be a promising technology for the replacement or treatment of diseased tissues and organs. Conventional cell transplantation has been achieved by harvesting autologous cells derived from the patients or stem cells. However, considering the long term process of cell culture in a sterile environment, it is crucial to develop new biomaterials that enhance the regeneration of damaged tissue by directing cellular organization. To this end, the authors focused on structure and function of extracellular matrix (ECM) at subcellular scale (tens to hundreds of nanometers), and envisioned to recapitulate the microstructure of ECM on a polymeric ultrathin film (nanosheet). In this paper, I introduce the fabrication and functionalization of nanosheets by integrating self-assembly of biomacromolecules and microfabrication techniques towards tissue engineering and regenerative medicine.",
keywords = "Basement membrane, Extracellular matrix, Microfabrication, Nanosheets, Tissue engineering",
author = "Toshinori Fujie",
year = "2014",
month = "9",
day = "1",
language = "English",
volume = "71",
pages = "408--417",
journal = "Kobunshi Ronbunshu",
issn = "0386-2186",
publisher = "Society of Polymer Science",
number = "9",

}

TY - JOUR

T1 - Development of polymer nanosheets inspired by extracellular matrix towards tissue engineering applications

AU - Fujie, Toshinori

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Along with the development of regenerative medicine represented by stem cell engineering, tissue engineering is expected to be a promising technology for the replacement or treatment of diseased tissues and organs. Conventional cell transplantation has been achieved by harvesting autologous cells derived from the patients or stem cells. However, considering the long term process of cell culture in a sterile environment, it is crucial to develop new biomaterials that enhance the regeneration of damaged tissue by directing cellular organization. To this end, the authors focused on structure and function of extracellular matrix (ECM) at subcellular scale (tens to hundreds of nanometers), and envisioned to recapitulate the microstructure of ECM on a polymeric ultrathin film (nanosheet). In this paper, I introduce the fabrication and functionalization of nanosheets by integrating self-assembly of biomacromolecules and microfabrication techniques towards tissue engineering and regenerative medicine.

AB - Along with the development of regenerative medicine represented by stem cell engineering, tissue engineering is expected to be a promising technology for the replacement or treatment of diseased tissues and organs. Conventional cell transplantation has been achieved by harvesting autologous cells derived from the patients or stem cells. However, considering the long term process of cell culture in a sterile environment, it is crucial to develop new biomaterials that enhance the regeneration of damaged tissue by directing cellular organization. To this end, the authors focused on structure and function of extracellular matrix (ECM) at subcellular scale (tens to hundreds of nanometers), and envisioned to recapitulate the microstructure of ECM on a polymeric ultrathin film (nanosheet). In this paper, I introduce the fabrication and functionalization of nanosheets by integrating self-assembly of biomacromolecules and microfabrication techniques towards tissue engineering and regenerative medicine.

KW - Basement membrane

KW - Extracellular matrix

KW - Microfabrication

KW - Nanosheets

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=84908365872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908365872&partnerID=8YFLogxK

M3 - Article

VL - 71

SP - 408

EP - 417

JO - Kobunshi Ronbunshu

JF - Kobunshi Ronbunshu

SN - 0386-2186

IS - 9

ER -