TY - JOUR
T1 - Development of supramolecular saccharide sensors based on cyclodextrin complexes and self-assembling systems
AU - Tsuchido, Yuji
AU - Fujiwara, Shoji
AU - Hashimoto, Takeshi
AU - Hayashita, Takashi
N1 - Funding Information:
This work was financially supported by Grants-in-Aid for Scientific Research (A) (Grant No. JP26248038) and Scientific Research (C) (Grant No. JP15K05548) from Japan Society for the Promotion of Science (JSPS). We are most proud of all the students who have contributed in the present research in our analytical chemistry group at Sophia University.
Publisher Copyright:
© 2017 The Pharmaceutical Society of Japan.
PY - 2017
Y1 - 2017
N2 - Cyclodextrins (CDs) are water-soluble host compounds having nano-size hydrophobic cavities that enable them to incorporate organic molecules in water. Optically inert CDs can be efficiently combined with various types of chromoionophores and fluoroionophores. In this study, using diverse combinations of phenylboronic acid fluorescent sensors and azoprobes with CDs, the unique saccharide recognition functions of CD, chemically modified CD, and CD gel complexes based on their synergistic function are clarified, thereby confirming their use as supramolecular saccharide sensors. To realize novel supramolecular chirality, the twisted structure of two ditopic azoprobes inside the γ-CD chiral cavity is controlled by multi-point recognition of guest ions in water. As different types of supramolecular saccharide sensors, phenylboronic acidbased self-assembling systems are also reviewed.
AB - Cyclodextrins (CDs) are water-soluble host compounds having nano-size hydrophobic cavities that enable them to incorporate organic molecules in water. Optically inert CDs can be efficiently combined with various types of chromoionophores and fluoroionophores. In this study, using diverse combinations of phenylboronic acid fluorescent sensors and azoprobes with CDs, the unique saccharide recognition functions of CD, chemically modified CD, and CD gel complexes based on their synergistic function are clarified, thereby confirming their use as supramolecular saccharide sensors. To realize novel supramolecular chirality, the twisted structure of two ditopic azoprobes inside the γ-CD chiral cavity is controlled by multi-point recognition of guest ions in water. As different types of supramolecular saccharide sensors, phenylboronic acidbased self-assembling systems are also reviewed.
KW - Cyclodextrin (CD)
KW - Phenylboronic acid
KW - Saccharide recognition
KW - Self-assembling system
KW - Supramolecular chirality
KW - Supramolecular sensor
UR - http://www.scopus.com/inward/record.url?scp=85017303032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017303032&partnerID=8YFLogxK
U2 - 10.1248/cpb.c16-00963
DO - 10.1248/cpb.c16-00963
M3 - Review article
C2 - 28381670
AN - SCOPUS:85017303032
SN - 0009-2363
VL - 65
SP - 318
EP - 325
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 4
ER -