Diagnostic accuracy of serological kits for Helicobacter pylori infection with the same assay system but different antigens in a Japanese patient population

Yuki Obata, Shogo Kikuchi, Hiroto Miwa, Kiyoko Yagyu, Yingsong Lin, Atsushi Ogihara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Helicobacter pylori infection is thought to be a causal risk factor for gastric carcinoma. Recently, diagnostic accuracy of serological kits for H. pylori infection that were made in Western countries has been reported to be lower when used among Oriental populations. Diagnostic accuracy of two serological kits [HM-CAP and HM-CAP with antigens extracted from clinically isolated Japanese H. pylori strains (J-HM-CAP)] was investigated in 440 samples from a Japanese patient population by using the 13C-urea breath test as gold standard. According to the original optimal cut-off value, HM-CAP provided 87.5% sensitivity and 84.8% specificity with 86.8% accuracy and J-HM-CAP provided 95.5% sensitivity and 81.9% specificity with 92.3% accuracy. This study suggests that antigens from HM-CAP are satisfactory for examining a Japanese patient population, but that using local antigens improves accuracy.

Original languageEnglish
Pages (from-to)889-892
Number of pages4
JournalJournal of Medical Microbiology
Volume52
Issue number10
DOIs
Publication statusPublished - 2003 Oct 1

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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