TY - JOUR
T1 - Dietary and microbial metabolites in the regulation of host immunity
AU - Shibata, Naoko
AU - Kunisawa, Jun
AU - Kiyono, Hiroshi
N1 - Funding Information:
This review article contains results obtained from our studies that were supported at least in part by grants from the Core Research for Evolutional Science and Technology Program of the Japan Agency for Medical Research and Development (HK); by the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Grants-in-Aid for Scientific Research S [HK; 23229004], for Scientific Research B [JK; 26293111], for Scientific Research on Innovative Areas [JK; 16H01373], for Young Scientists B [NS; 17K17686], and for a JSPS Research Fellow [NS; 17J07480]); by the Practical Research Project for Allergic Diseases and Immunology (Research on Allergic Diseases and Immunology) and for the Research on Development of New Drugs (Adjuvant Database Project) from the Japan Agency for Medical Research and Development (AMED; JK, and HK) and by the Ministry of Health, Labour and Welfare (MHLW) (JK); by the Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry (JK); and by the Astellas Foundation for Research on Metabolic Disorders (JK), the Public Health Research Foundation for Public Health Science (NS), the Terumo Foundation for Life Science and Arts (JK), and the Suzuken Memorial Foundation (JK).
Publisher Copyright:
© 2017 Shibata, Kunisawa and Kiyono.
PY - 2017/11/7
Y1 - 2017/11/7
N2 - Mucosal surfaces in the body, especially the intestine, are constantly exposed to trillions of microbiomes. Accumulating evidence has revealed that changes in the composition of the gut microbiome, especially that of the commensal bacteria population, are frequently associated with immunologic disorders. These changes coincide with changes in the production of certain dietary metabolites. Recent studies have uncovered the molecular and cellular mechanisms underlying the relationships among diet, commensal bacteria, and the host immune system. In this review, we describe how dietary and microbial metabolites modulate host immunity.
AB - Mucosal surfaces in the body, especially the intestine, are constantly exposed to trillions of microbiomes. Accumulating evidence has revealed that changes in the composition of the gut microbiome, especially that of the commensal bacteria population, are frequently associated with immunologic disorders. These changes coincide with changes in the production of certain dietary metabolites. Recent studies have uncovered the molecular and cellular mechanisms underlying the relationships among diet, commensal bacteria, and the host immune system. In this review, we describe how dietary and microbial metabolites modulate host immunity.
KW - Fatty acid
KW - Metabolite
KW - Microbiome
KW - Vitamin
UR - http://www.scopus.com/inward/record.url?scp=85033784875&partnerID=8YFLogxK
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U2 - 10.3389/fmicb.2017.02171
DO - 10.3389/fmicb.2017.02171
M3 - Review article
AN - SCOPUS:85033784875
SN - 1664-302X
VL - 8
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
IS - NOV
M1 - 2171
ER -