Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats

Pham Hung, Shihoko Kaku, Shin Ichi Yunoki, Ken Ichi Ohkura, Jiong Yan Gu, Ikuo Ikeda, Michihiro Sugano, Kazunaga Yazawa, Koji Yamada

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume63
Issue number1
Publication statusPublished - 1999 Jan
Externally publishedYes

Fingerprint

fatty fish
Eicosapentaenoic Acid
Docosahexaenoic Acids
Fish Oils
eicosapentaenoic acid
docosahexaenoic acid
Fish
Sprague Dawley Rats
Rats
fish oils
lymph nodes
Acids
rats
lymphocytes
Lymphocytes
safflower oil
splenocytes
arachidonic acid
dietary fat
Immunoglobulin G

Keywords

  • Fatty acid
  • Fish oil
  • Histamine
  • Immunoglobulin
  • Leukotriene

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Hung, P., Kaku, S., Yunoki, S. I., Ohkura, K. I., Gu, J. Y., Ikeda, I., ... Yamada, K. (1999). Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. Bioscience, Biotechnology and Biochemistry, 63(1), 135-140.

Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. / Hung, Pham; Kaku, Shihoko; Yunoki, Shin Ichi; Ohkura, Ken Ichi; Gu, Jiong Yan; Ikeda, Ikuo; Sugano, Michihiro; Yazawa, Kazunaga; Yamada, Koji.

In: Bioscience, Biotechnology and Biochemistry, Vol. 63, No. 1, 01.1999, p. 135-140.

Research output: Contribution to journalArticle

Hung, P, Kaku, S, Yunoki, SI, Ohkura, KI, Gu, JY, Ikeda, I, Sugano, M, Yazawa, K & Yamada, K 1999, 'Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats', Bioscience, Biotechnology and Biochemistry, vol. 63, no. 1, pp. 135-140.
Hung, Pham ; Kaku, Shihoko ; Yunoki, Shin Ichi ; Ohkura, Ken Ichi ; Gu, Jiong Yan ; Ikeda, Ikuo ; Sugano, Michihiro ; Yazawa, Kazunaga ; Yamada, Koji. / Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. In: Bioscience, Biotechnology and Biochemistry. 1999 ; Vol. 63, No. 1. pp. 135-140.
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