Abstract
The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.
| Original language | English |
|---|---|
| Pages (from-to) | 135-140 |
| Number of pages | 6 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 63 |
| Issue number | 1 |
| Publication status | Published - 1999 Jan |
| Externally published | Yes |
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Keywords
- Fatty acid
- Fish oil
- Histamine
- Immunoglobulin
- Leukotriene
ASJC Scopus subject areas
- Food Science
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biotechnology
- Chemistry (miscellaneous)
- Applied Microbiology and Biotechnology
- Bioengineering
Cite this
Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. / Hung, Pham; Kaku, Shihoko; Yunoki, Shin Ichi; Ohkura, Ken Ichi; Gu, Jiong Yan; Ikeda, Ikuo; Sugano, Michihiro; Yazawa, Kazunaga; Yamada, Koji.
In: Bioscience, Biotechnology and Biochemistry, Vol. 63, No. 1, 01.1999, p. 135-140.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats
AU - Hung, Pham
AU - Kaku, Shihoko
AU - Yunoki, Shin Ichi
AU - Ohkura, Ken Ichi
AU - Gu, Jiong Yan
AU - Ikeda, Ikuo
AU - Sugano, Michihiro
AU - Yazawa, Kazunaga
AU - Yamada, Koji
PY - 1999/1
Y1 - 1999/1
N2 - The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.
AB - The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.
KW - Fatty acid
KW - Fish oil
KW - Histamine
KW - Immunoglobulin
KW - Leukotriene
UR - http://www.scopus.com/inward/record.url?scp=0032610565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032610565&partnerID=8YFLogxK
M3 - Article
C2 - 10052133
AN - SCOPUS:0032610565
VL - 63
SP - 135
EP - 140
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 1
ER -