Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats

Pham Hung, Jiong Yan Gu, Shihoko Kaku, Shin Ichi Yunoki, Ken Ichi Ohkura, Ikuo Ikeda, Hirofumi Tachibana, Michihiro Sugano, Kazunaga Yazawa, Koji Yamada

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Sprague-Dawley rats were fed eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) ethyl esters at the 2% level for 3 weeks to clarify their effects on immune functions. In the rats fed EPA or DHA, serum cholesterol, triglyceride, and phospholipid (PL) levels were significantly lower than those in the rats fed safflower oil. In PL fractions of serum, liver, lung, splenocytes, and peritoneal exudate cells (PEC), increases in linoleic and dihomo-γ-linolenic acid contents and a decrease in arachidonic acid (AA) content were observed in the rats fed EPA or DHA. In addition, the EPA content increased in the rats fed EPA and DHA. In the rats fed EPA or DHA, a decrease of LTB4 productivity and an increase of LTB5 productivity were observed in the PEC, in response to the treatment with 5 μM calcium ionophore A23187 for 20 min. The changes in leukotriene production were more marked in EPA-fed rats than in DHA-fed rats. These results suggest that dietary EPA affects lipid metabolism and leukotriene synthesis more strongly than DHA.

Original languageEnglish
Pages (from-to)2588-2593
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number12
Publication statusPublished - 2000 Dec
Externally publishedYes

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Eicosapentaenoic Acid
Docosahexaenoic Acids
eicosapentaenoic acid
docosahexaenoic acid
Lipid Metabolism
lipid metabolism
Sprague Dawley Rats
Rats
Esters
esters
Acids
rats
Leukotrienes
leukotrienes
Exudates and Transudates
Phospholipids
phospholipids
Safflower Oil
Productivity
Leukotriene B4

Keywords

  • DHA
  • EPA
  • Fatty acid composition
  • LTB
  • LTB

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Hung, P., Gu, J. Y., Kaku, S., Yunoki, S. I., Ohkura, K. I., Ikeda, I., ... Yamada, K. (2000). Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats. Bioscience, Biotechnology and Biochemistry, 64(12), 2588-2593.

Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats. / Hung, Pham; Gu, Jiong Yan; Kaku, Shihoko; Yunoki, Shin Ichi; Ohkura, Ken Ichi; Ikeda, Ikuo; Tachibana, Hirofumi; Sugano, Michihiro; Yazawa, Kazunaga; Yamada, Koji.

In: Bioscience, Biotechnology and Biochemistry, Vol. 64, No. 12, 12.2000, p. 2588-2593.

Research output: Contribution to journalArticle

Hung, P, Gu, JY, Kaku, S, Yunoki, SI, Ohkura, KI, Ikeda, I, Tachibana, H, Sugano, M, Yazawa, K & Yamada, K 2000, 'Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats', Bioscience, Biotechnology and Biochemistry, vol. 64, no. 12, pp. 2588-2593.
Hung, Pham ; Gu, Jiong Yan ; Kaku, Shihoko ; Yunoki, Shin Ichi ; Ohkura, Ken Ichi ; Ikeda, Ikuo ; Tachibana, Hirofumi ; Sugano, Michihiro ; Yazawa, Kazunaga ; Yamada, Koji. / Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats. In: Bioscience, Biotechnology and Biochemistry. 2000 ; Vol. 64, No. 12. pp. 2588-2593.
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