Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g

Chie Matsuda, Tamotsu Kato, Sayo Inoue-Suzuki, Jun Kikuchi, Toshiko Ohta, Masaharu Kagawa, Masahira Hattori, Hiroe Kobayashi, Dai Shiba, Masaki Shirakawa, Hiroyasu Mizuno, Satoshi Furukawa, Chiaki Mukai, Hiroshi Ohno

Research output: Contribution to journalArticle

Abstract

Japan Aerospace Exploration Agency (JAXA) has developed mouse habitat cage units equipped with an artificial gravity-producing centrifuge, called the Multiple Artificial-gravity Research System (MARS), that enables single housing of a mouse under artificial gravity (AG) in orbit. This is a report on a hardware evaluation. The MARS underwent improvement in water leakage under microgravity (MG), and was used in the second JAXA mouse mission to evaluate the effect of AG and diet on mouse biological system simultaneously. Twelve mice were divided into four groups of three, with each group fed a diet either with or without fructo-oligosaccharide and housed singly either at 1 g AG or MG for 30 days on the International Space Station, then safely returned to the Earth. Body weight tended to increase in AG mice and decrease in MG mice after spaceflight, but these differences were not significant. This indicates that the improved MARS may be useful in evaluating AG and dietary intervention for space flown mice.

Original languageEnglish
Article number16
Journalnpj Microgravity
Volume5
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

Fingerprint

Altered Gravity
artificial gravity
gravity
mice
Gravitation
Research
microgravity
Weightlessness
Microgravity
diets
Nutrition
Japan
diet
Diet
space flight
body weight
centrifuges
Space Flight
Oligosaccharides
habitats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Agricultural and Biological Sciences (miscellaneous)
  • Physics and Astronomy (miscellaneous)
  • Space and Planetary Science

Cite this

Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g. / Matsuda, Chie; Kato, Tamotsu; Inoue-Suzuki, Sayo; Kikuchi, Jun; Ohta, Toshiko; Kagawa, Masaharu; Hattori, Masahira; Kobayashi, Hiroe; Shiba, Dai; Shirakawa, Masaki; Mizuno, Hiroyasu; Furukawa, Satoshi; Mukai, Chiaki; Ohno, Hiroshi.

In: npj Microgravity, Vol. 5, No. 1, 16, 01.12.2019.

Research output: Contribution to journalArticle

Matsuda, C, Kato, T, Inoue-Suzuki, S, Kikuchi, J, Ohta, T, Kagawa, M, Hattori, M, Kobayashi, H, Shiba, D, Shirakawa, M, Mizuno, H, Furukawa, S, Mukai, C & Ohno, H 2019, 'Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g', npj Microgravity, vol. 5, no. 1, 16. https://doi.org/10.1038/s41526-019-0077-0
Matsuda, Chie ; Kato, Tamotsu ; Inoue-Suzuki, Sayo ; Kikuchi, Jun ; Ohta, Toshiko ; Kagawa, Masaharu ; Hattori, Masahira ; Kobayashi, Hiroe ; Shiba, Dai ; Shirakawa, Masaki ; Mizuno, Hiroyasu ; Furukawa, Satoshi ; Mukai, Chiaki ; Ohno, Hiroshi. / Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g. In: npj Microgravity. 2019 ; Vol. 5, No. 1.
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