TY - JOUR
T1 - Different Molecular Mechanisms Underlie Placental Overgrowth Phenotypes Caused by Interspecies Hybridization, Cloning, and Esx1 Mutation
AU - Singh, Umashankar
AU - Fohn, Laurel E.
AU - Wakayama, Teruhiko
AU - Ohgane, Jun
AU - Steinhoff, Christine
AU - Lipkowitz, Bettina
AU - Schulz, Ralph
AU - Orth, Annie
AU - Ropers, H. Hilger
AU - Behringer, Richard R.
AU - Tanaka, Satoshi
AU - Shiota, Kunio
AU - Yanagimachi, Ryuzo
AU - Nuber, Ulrike A.
AU - Fundele, Reinald
PY - 2004/5
Y1 - 2004/5
N2 - To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia caused by interspecies hybridization (IHPD), cloning by nuclear transfer, and mutation of the Esx1 gene, respectively. Comparison of gene expression profiles of approximately 13,000 expressed sequence tags (ESTs) identified specific subsets of genes with changed expression levels in IHPD, cloned, and Esx1 mutant placentas. Of interest, only one gene of known function and one EST of unknown function were found common to all three placentopathies; however, a significant number of ESTs were common to IHPD and cloned placentas. In contrast, only one gene was shared between IHPD and Esx1 mutant, and cloned and Esx1 mutant placentas, respectively. These genes common to different abnormal placental growth genotypes are likely to be important in the occurrence of placentopathy.
AB - To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia caused by interspecies hybridization (IHPD), cloning by nuclear transfer, and mutation of the Esx1 gene, respectively. Comparison of gene expression profiles of approximately 13,000 expressed sequence tags (ESTs) identified specific subsets of genes with changed expression levels in IHPD, cloned, and Esx1 mutant placentas. Of interest, only one gene of known function and one EST of unknown function were found common to all three placentopathies; however, a significant number of ESTs were common to IHPD and cloned placentas. In contrast, only one gene was shared between IHPD and Esx1 mutant, and cloned and Esx1 mutant placentas, respectively. These genes common to different abnormal placental growth genotypes are likely to be important in the occurrence of placentopathy.
KW - Clones
KW - Esx1
KW - Global gene expression
KW - IHPD
KW - Placental hyperplasia
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U2 - 10.1002/dvdy.20024
DO - 10.1002/dvdy.20024
M3 - Article
C2 - 15108320
AN - SCOPUS:11144354460
VL - 230
SP - 149
EP - 164
JO - American Journal of Anatomy
JF - American Journal of Anatomy
SN - 1058-8388
IS - 1
ER -