Different recovery responses from dietary zinc-deficiency in the distribution of rat granulocytes

Yuko Sakakibara, Shogo Sato, Yu Kawashima, Yui Someya, Ken Shirato, Kaoru Tachiyashiki, Kazuhiko Imaizumi

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The purpose of this study was to elucidate the effects of the recovery from dietary zinc-deficiency on the number of total white blood cells (WBCs), neutrophils, eosinophils and basophils, and plasma zinc and corticosterone concentrations in weanling male Sprague Dawley rats. Rats (n= 34) of the zinc-deficient diet (0.6 mg zinc/kg diet) and control diet (35.2 mg zinc/kg diet) groups were fed for 4 wk, and then rats of both groups were fed with the control diet for 3 wk. Zinc-deficiency increased duration-dependently and clearly the number of total WBCs, neutrophils and eosinophils, and the increased numbers of these cells recovered to the control levels in week 2 of the recovery. On the other hand, the number of basophils increased by the zinc-deficiency recovered to the control levels in week 1 of the recovery. Zinc-deficiency significantly decreased plasma zinc concentrations by 85%, and markedly increased plasma corticosterone concentrations by 317%, as compared with the control group. In the recovery period, plasma zinc and corticosterone concentrations recovered to the control levels in week 2 of the recovery. These results suggest that zinc-deficiency and its recovery responses in the number of granulocytes and total WBCs are reversible, and their recovery rates depend on the subsets of granulocytes in rats.

    Original languageEnglish
    Pages (from-to)197-201
    Number of pages5
    JournalJournal of Nutritional Science and Vitaminology
    Volume57
    Issue number2
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Granulocytes
    Zinc
    Diet
    Corticosterone
    Leukocytes
    Basophils
    Eosinophils
    Neutrophils
    Sprague Dawley Rats
    Cell Count
    Control Groups

    Keywords

    • Basophils
    • Granulocytes
    • Neutrophils
    • Plasma zinc and corticosterone concentrations
    • Zinc-deficiency and its recovery

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

    Cite this

    Sakakibara, Y., Sato, S., Kawashima, Y., Someya, Y., Shirato, K., Tachiyashiki, K., & Imaizumi, K. (2011). Different recovery responses from dietary zinc-deficiency in the distribution of rat granulocytes. Journal of Nutritional Science and Vitaminology, 57(2), 197-201. https://doi.org/10.3177/jnsv.57.197

    Different recovery responses from dietary zinc-deficiency in the distribution of rat granulocytes. / Sakakibara, Yuko; Sato, Shogo; Kawashima, Yu; Someya, Yui; Shirato, Ken; Tachiyashiki, Kaoru; Imaizumi, Kazuhiko.

    In: Journal of Nutritional Science and Vitaminology, Vol. 57, No. 2, 2011, p. 197-201.

    Research output: Contribution to journalArticle

    Sakakibara, Y, Sato, S, Kawashima, Y, Someya, Y, Shirato, K, Tachiyashiki, K & Imaizumi, K 2011, 'Different recovery responses from dietary zinc-deficiency in the distribution of rat granulocytes', Journal of Nutritional Science and Vitaminology, vol. 57, no. 2, pp. 197-201. https://doi.org/10.3177/jnsv.57.197
    Sakakibara, Yuko ; Sato, Shogo ; Kawashima, Yu ; Someya, Yui ; Shirato, Ken ; Tachiyashiki, Kaoru ; Imaizumi, Kazuhiko. / Different recovery responses from dietary zinc-deficiency in the distribution of rat granulocytes. In: Journal of Nutritional Science and Vitaminology. 2011 ; Vol. 57, No. 2. pp. 197-201.
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