Differential acylated ghrelin, peptide YY3-36, appetite, and food intake responses to equivalent energy deficits created by exercise and food restriction

James A. King, Lucy K. Wasse, Joshua Ewens, Kathrina Crystallis, Julian Emmanuel, Rachel L. Batterham, David J. Stensel

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)

Abstract

Context: Acute energy deficits imposed by food restriction increase appetite and energy intake; however, these outcomes remain unchanged when energy deficits are imposed by exercise. Objective:Ourobjectivewasto determine the potential role of acylated ghrelinandpeptideYY3-36 (PYY 3-36) in mediating appetite and energy intake responses to identical energy deficits imposed by food restriction and exercise. Design: Twelve healthy males completed three 9-h trials (exercise deficit, food deficit, and control) in a randomized counterbalanced design. Participants ran for 90 min (70% of VO2 max) at the beginning of the exercise deficit trial and then rested for 7.5 h. Participants remained sedentary throughout the food deficit and control trials. Test meals were consumed by participants at 2 and 4.75 h in all trials. The amount provided in the food deficit trial was restricted so that an energy deficit (equivalent to that imposed by exercise) was induced relative to control. Participants were permitted access to a buffet meal at 8 h. Results: The energy deficits imposed by food restriction (4820 ± 151 kJ) and exercise (4715 ± 113 kJ) were similar. Appetite and ad libitum energy intake responded in a compensatory fashion to food restriction yet were not influenced by exercise. Plasma acylated ghrelin concentrations increased, whereas PYY3-36 decreased, in response to food restriction (two-way ANOVA, trial×time interaction, P < 0.001 for each). Exercise did not induce such compensatory responses. Conclusions: These findings suggest a mediating role of acylated ghrelin and PYY3-36 in determining divergent feeding responses to energy deficits imposed by food restriction and exercise.

Original languageEnglish
Pages (from-to)1114-1121
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number4
DOIs
Publication statusPublished - 2011 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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