Differential effect of lithium on the circadian oscillator in young and old hamsters

Eiko Iwahana, Toshiyuki Hamada, Ayumi Uchida, Shigenobu Shibata

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Lithium is one of the most commonly used drugs in the prophylaxis and treatment of bipolar disorder. It is also known to lengthen circadian period in several organisms. Previously, we reported that there was the association between lengthening circadian period by lithium and GSK-3 protein and its enzyme activity in the mouse suprachiasmatic nucleus (SCN). In this study, we show that lithium affects the circadian oscillator in young and old hamster SCN, in an age-dependent manner. We found that basal levels of phosphorylated GSK-3 (pGSK-3) protein expression in old hamsters are much lower than that in young hamsters. Furthermore, in the old hamsters, lithium did not affect the period of the locomotor activity rhythm or pGSK-3 expression, while changing period and pGSK-3 in the younger animals. These results indicate that the content of pGSK-3 in the SCN has an important role in age-dependent effects of lithium on the circadian oscillator.

    Original languageEnglish
    Pages (from-to)752-756
    Number of pages5
    JournalBiochemical and Biophysical Research Communications
    Volume354
    Issue number3
    DOIs
    Publication statusPublished - 2007 Mar 16

    Fingerprint

    Glycogen Synthase Kinase 3
    Lithium
    Cricetinae
    Suprachiasmatic Nucleus
    Enzyme activity
    Locomotion
    Bipolar Disorder
    Animals
    Proteins
    Enzymes
    Pharmaceutical Preparations

    Keywords

    • Aging
    • Bipolar disorder
    • Circadian rhythm
    • GSK-3
    • Hamster
    • Lithium
    • Mouse
    • SCN
    • Suprachiasmatic nucleus

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    Differential effect of lithium on the circadian oscillator in young and old hamsters. / Iwahana, Eiko; Hamada, Toshiyuki; Uchida, Ayumi; Shibata, Shigenobu.

    In: Biochemical and Biophysical Research Communications, Vol. 354, No. 3, 16.03.2007, p. 752-756.

    Research output: Contribution to journalArticle

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