Differential Effects of Electroconvulsive Shock on Four Models of Experimentally-Induced Aggression in Rats

Shyh Yuh Liou; Shigenobu Shibata; Showa Ueki

doi:10.1254/jjp.37.167

Differential Effects of Electroconvulsive Shock on Four Models of Experimentally-Induced Aggression in Rats

Shyh Yuh Liou, Shigenobu Shibata, Showa Ueki

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The effects of electroconvulsive shock (ECS) on the hyperemotionality and muricide in olfactory bulbectonnized rats (OB rat) were compared with those in spontaneous killer rats (SP rat), raphe lesioned rats (Raphe rat) and z9-tetra-hydrocannabinol treated rats (THC rat). Single and chronic treatment of ECS inhibited the muricide and attack response to a rod, but did not affect the struggle response to handling and flight response to air blowing. Muricide was markedly inhibited by ECS in OB and SP rats, and was moderately inhibited in THC rats, while it was slightly inhibited in Raphe rats. The present result indicates that muricide of OB rats is a useful model for evaluating antidepressant drugs as this behavior is markedly inhibited by ECS in OB rats. Furthermore, it is suggested that the effect of ECS on muricide is different depending upon the methods to induce muricide, although muricide itself seems to be behaviorally similar.

Original language	English
Pages (from-to)	167-172
Number of pages	6
Journal	The Japanese Journal of Pharmacology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1254/jjp.37.167
Publication status	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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title = "Differential Effects of Electroconvulsive Shock on Four Models of Experimentally-Induced Aggression in Rats",

abstract = "The effects of electroconvulsive shock (ECS) on the hyperemotionality and muricide in olfactory bulbectonnized rats (OB rat) were compared with those in spontaneous killer rats (SP rat), raphe lesioned rats (Raphe rat) and z9-tetra-hydrocannabinol treated rats (THC rat). Single and chronic treatment of ECS inhibited the muricide and attack response to a rod, but did not affect the struggle response to handling and flight response to air blowing. Muricide was markedly inhibited by ECS in OB and SP rats, and was moderately inhibited in THC rats, while it was slightly inhibited in Raphe rats. The present result indicates that muricide of OB rats is a useful model for evaluating antidepressant drugs as this behavior is markedly inhibited by ECS in OB rats. Furthermore, it is suggested that the effect of ECS on muricide is different depending upon the methods to induce muricide, although muricide itself seems to be behaviorally similar.",

author = "Liou, {Shyh Yuh} and Shigenobu Shibata and Showa Ueki",

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AU - Liou, Shyh Yuh

AU - Shibata, Shigenobu

AU - Ueki, Showa

PY - 1985

Y1 - 1985

N2 - The effects of electroconvulsive shock (ECS) on the hyperemotionality and muricide in olfactory bulbectonnized rats (OB rat) were compared with those in spontaneous killer rats (SP rat), raphe lesioned rats (Raphe rat) and z9-tetra-hydrocannabinol treated rats (THC rat). Single and chronic treatment of ECS inhibited the muricide and attack response to a rod, but did not affect the struggle response to handling and flight response to air blowing. Muricide was markedly inhibited by ECS in OB and SP rats, and was moderately inhibited in THC rats, while it was slightly inhibited in Raphe rats. The present result indicates that muricide of OB rats is a useful model for evaluating antidepressant drugs as this behavior is markedly inhibited by ECS in OB rats. Furthermore, it is suggested that the effect of ECS on muricide is different depending upon the methods to induce muricide, although muricide itself seems to be behaviorally similar.

AB - The effects of electroconvulsive shock (ECS) on the hyperemotionality and muricide in olfactory bulbectonnized rats (OB rat) were compared with those in spontaneous killer rats (SP rat), raphe lesioned rats (Raphe rat) and z9-tetra-hydrocannabinol treated rats (THC rat). Single and chronic treatment of ECS inhibited the muricide and attack response to a rod, but did not affect the struggle response to handling and flight response to air blowing. Muricide was markedly inhibited by ECS in OB and SP rats, and was moderately inhibited in THC rats, while it was slightly inhibited in Raphe rats. The present result indicates that muricide of OB rats is a useful model for evaluating antidepressant drugs as this behavior is markedly inhibited by ECS in OB rats. Furthermore, it is suggested that the effect of ECS on muricide is different depending upon the methods to induce muricide, although muricide itself seems to be behaviorally similar.

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Differential Effects of Electroconvulsive Shock on Four Models of Experimentally-Induced Aggression in Rats

Abstract

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