TY - JOUR
T1 - Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194
AU - Izuta, Shoko
AU - Kosaka, Shohei
AU - Kawai, Makoto
AU - Miyano, Rei
AU - Matsuo, Hirotaka
AU - Matsumoto, Atsuko
AU - Nonaka, Kenichi
AU - Takahashi, Yoko
AU - Omura, Satoshi
AU - Nakashima, Takuji
N1 - Funding Information:
This project was supported by JSPS KAKENHI Grant Number 17K08342 and the Institute for Fermentation, Osaka (IFO), Japan. We are grateful to Dr Masato Iwatsuki, Kitasato Institute for Life Sciences, Kitasato University, Mr Hirohumi Honda, Fuji Silysia Chemical Ltd., for helpful advice, and Dr Kenichiro Nagai and Ms Noriko Sato, School of Pharmacy, Kitasato University, for measurement of MS and NMR spectra
Funding Information:
Acknowledgements This project was supported by JSPS KAKENHI Grant Number 17K08342 and the Institute for Fermentation, Osaka (IFO), Japan. We are grateful to Dr Masato Iwatsuki, Kitasato Institute for Life Sciences, Kitasato University, Mr Hirohumi Honda, Fuji Silysia Chemical Ltd., for helpful advice, and Dr Kenichiro Nagai and Ms Noriko Sato, School of Pharmacy, Kitasato University, for measurement of MS and NMR spectra.
Publisher Copyright:
© 2018 The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - In a search for compounds interacting with ergosterol resin, a new compound named dipyrimicin B was isolated from a rare actinomycete strain, Amycolatopsis sp. K16-0194. In addition, another analog, dipyrimicin A, which does not interact with the resin, was also discovered. The structures of the two dipyrimicins were established by comprehensive 1D and 2D NMR and MS analyses and found to contain a unique core structure, a 2,2′-bipyridine skeleton. Dipyrimicin A showed strong antimicrobial and cytotoxic activity, whereas dipyrimicin B displayed distinctly poor antimicrobial and cytotoxic activities.
AB - In a search for compounds interacting with ergosterol resin, a new compound named dipyrimicin B was isolated from a rare actinomycete strain, Amycolatopsis sp. K16-0194. In addition, another analog, dipyrimicin A, which does not interact with the resin, was also discovered. The structures of the two dipyrimicins were established by comprehensive 1D and 2D NMR and MS analyses and found to contain a unique core structure, a 2,2′-bipyridine skeleton. Dipyrimicin A showed strong antimicrobial and cytotoxic activity, whereas dipyrimicin B displayed distinctly poor antimicrobial and cytotoxic activities.
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U2 - 10.1038/s41429-018-0028-0
DO - 10.1038/s41429-018-0028-0
M3 - Article
C2 - 29463887
AN - SCOPUS:85042219428
SN - 0021-8820
VL - 71
SP - 535
EP - 537
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 5
ER -