Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194

Shoko Izuta, Shohei Kosaka, Makoto Kawai, Rei Miyano, Hirotaka Matsuo, Atsuko Matsumoto, Kenichi Nonaka, Yoko Takahashi, Satoshi Omura, Takuji Nakashima*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


In a search for compounds interacting with ergosterol resin, a new compound named dipyrimicin B was isolated from a rare actinomycete strain, Amycolatopsis sp. K16-0194. In addition, another analog, dipyrimicin A, which does not interact with the resin, was also discovered. The structures of the two dipyrimicins were established by comprehensive 1D and 2D NMR and MS analyses and found to contain a unique core structure, a 2,2′-bipyridine skeleton. Dipyrimicin A showed strong antimicrobial and cytotoxic activity, whereas dipyrimicin B displayed distinctly poor antimicrobial and cytotoxic activities.

Original languageEnglish
Pages (from-to)535-537
Number of pages3
JournalJournal of Antibiotics
Issue number5
Publication statusPublished - 2018 May 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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