Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe 3 catalysis

Yoshiaki Nakao, Hiroaki Idei, Stephen Kyalo Kanyiva, Tamejiro Hiyama

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

(Chemical Equation Presented) Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe 3 catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).

Original languageEnglish
Pages (from-to)15996-15997
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number44
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Alkenylation
Pyridones
Alkylation
Nickel
Catalysis
Derivatives
Lewis Acids
Alkynes
Alkenes
Olefins
Chemical activation
Oxygen
Acids

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe 3 catalysis. / Nakao, Yoshiaki; Idei, Hiroaki; Kanyiva, Stephen Kyalo; Hiyama, Tamejiro.

In: Journal of the American Chemical Society, Vol. 131, No. 44, 2009, p. 15996-15997.

Research output: Contribution to journalArticle

Nakao, Yoshiaki ; Idei, Hiroaki ; Kanyiva, Stephen Kyalo ; Hiyama, Tamejiro. / Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe 3 catalysis. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 44. pp. 15996-15997.
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