Abstract
(Chemical Equation Presented) Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe 3 catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).
| Original language | English |
|---|---|
| Pages (from-to) | 15996-15997 |
| Number of pages | 2 |
| Journal | Journal of the American Chemical Society |
| Volume | 131 |
| Issue number | 44 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Biochemistry
- Colloid and Surface Chemistry
Cite this
Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe 3 catalysis. / Nakao, Yoshiaki; Idei, Hiroaki; Kanyiva, Stephen Kyalo; Hiyama, Tamejiro.
In: Journal of the American Chemical Society, Vol. 131, No. 44, 2009, p. 15996-15997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe 3 catalysis
AU - Nakao, Yoshiaki
AU - Idei, Hiroaki
AU - Kanyiva, Stephen Kyalo
AU - Hiyama, Tamejiro
PY - 2009
Y1 - 2009
N2 - (Chemical Equation Presented) Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe 3 catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).
AB - (Chemical Equation Presented) Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe 3 catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).
UR - http://www.scopus.com/inward/record.url?scp=70450191686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70450191686&partnerID=8YFLogxK
U2 - 10.1021/ja907214t
DO - 10.1021/ja907214t
M3 - Article
C2 - 19835373
AN - SCOPUS:70450191686
VL - 131
SP - 15996
EP - 15997
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 44
ER -