Direct alkenylation and alkylation of pyridone derivatives by Ni/AlMe 3 catalysis

Yoshiaki Nakao, Hiroaki Idei, Kyalo Stephen Kanyiva, Tamejiro Hiyama

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

(Chemical Equation Presented) Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe 3 catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).

Original languageEnglish
Pages (from-to)15996-15997
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number44
DOIs
Publication statusPublished - 2009 Nov 27

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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