Disposition control of metalloporphyrins as SOD mimics

Miho Tamai, Shoichiro Asayama, Shoji Nagaoka, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

Research output: Contribution to conferencePaper

Abstract

We have reported the effects of metalloporphyrins as SOD mimics on the anticancer and antioxidation. Fe-porphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally, H 2O2 and OH · generated by the Fe-porphyrin are expected to cause cell death. In this study, we have synthesized liposomes with water-soluble cationic metalloporphyrins as SOD mimic and have investigated the effect of the liposomes on cancer cell death. Liposomes were prepared using a sonication method. Cell viabilities of cell lines treated with Fe-porphyrins, liposomes containing Fe-porphyrins, and cisplatin were estimated by a Alamar Blue Assay. Liposomes containing Fe-porphyrins showed a significant cytotoxicity for cancer cell as compared with cisplatin.

Original languageEnglish
Pages5195-5196
Number of pages2
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Drug delivery system
  • Liposome
  • Metalloporphyrin
  • Signal Peptide

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Tamai, M., Asayama, S., Nagaoka, S., Oyaizu, K., Yuasa, M., & Kawakami, H. (2005). Disposition control of metalloporphyrins as SOD mimics. 5195-5196. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.