Disposition control of metalloporphyrins as SOD mimics

Miho Tamai, Shoichiro Asayama, Shoji Nagaoka, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have reported the effects of metalloporphyrins as SOD mimics on the anticancer and antioxidation. Fe-porphyrins as SOD mimics convert intracellular O2 - · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally, H 2O2 and OH · generated by the Fe-porphyrin are expected to cause cell death. In this study, we have synthesized liposomes with water-soluble cationic metalloporphyrins as SOD mimic and have investigated the effect of the liposomes on cancer cell death. Liposomes were prepared using a sonication method. Cell viabilities of cell lines treated with Fe-porphyrins, liposomes containing Fe-porphyrins, and cisplatin were estimated by a Alamar Blue Assay. Liposomes containing Fe-porphyrins showed a significant cytotoxicity for cancer cell as compared with cisplatin.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages5195-5196
Number of pages2
Volume54
Edition2
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CityYamagata
Period05/9/2005/9/22

Fingerprint

Porphyrins
Liposomes
Cells
Cell death
Sonication
Cytotoxicity
Assays
Iron
Water

Keywords

  • Drug delivery system
  • Liposome
  • Metalloporphyrin
  • Signal Peptide

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Tamai, M., Asayama, S., Nagaoka, S., Oyaizu, K., Yuasa, M., & Kawakami, H. (2005). Disposition control of metalloporphyrins as SOD mimics. In Polymer Preprints, Japan (2 ed., Vol. 54, pp. 5195-5196)

Disposition control of metalloporphyrins as SOD mimics. / Tamai, Miho; Asayama, Shoichiro; Nagaoka, Shoji; Oyaizu, Kenichi; Yuasa, Makoto; Kawakami, Hiroyoshi.

Polymer Preprints, Japan. Vol. 54 2. ed. 2005. p. 5195-5196.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tamai, M, Asayama, S, Nagaoka, S, Oyaizu, K, Yuasa, M & Kawakami, H 2005, Disposition control of metalloporphyrins as SOD mimics. in Polymer Preprints, Japan. 2 edn, vol. 54, pp. 5195-5196, 54th SPSJ Symposium on Macromolecules, Yamagata, 05/9/20.
Tamai M, Asayama S, Nagaoka S, Oyaizu K, Yuasa M, Kawakami H. Disposition control of metalloporphyrins as SOD mimics. In Polymer Preprints, Japan. 2 ed. Vol. 54. 2005. p. 5195-5196
Tamai, Miho ; Asayama, Shoichiro ; Nagaoka, Shoji ; Oyaizu, Kenichi ; Yuasa, Makoto ; Kawakami, Hiroyoshi. / Disposition control of metalloporphyrins as SOD mimics. Polymer Preprints, Japan. Vol. 54 2. ed. 2005. pp. 5195-5196
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