Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice

Katsutaka Oishi, Gen Ichi Atsumi, Shinobu Sugiyama, Ikuko Kodomari, Manami Kasamatsu, Kazuhiko Machida, Norio Ishida

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

The Clock gene is a core component of the circadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an increase in body weight induced by a high-fat diet was attenuated in homozygous Clock mutant mice. We also found that dietary fat absorption was extremely impaired in Clock mutant mice. Circadian expressions of cholecystokinin-A (CCK-A) receptor and lipase mRNAs were damped in the pancreas of Clock mutant mice. We therefore showed that a Clock mutation attenuates obesity induced by a high-fat diet in mice with an ICR background through impaired dietary fat absorption. Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalFEBS Letters
Volume580
Issue number1
DOIs
Publication statusPublished - 2006 Jan 9

Keywords

  • Cholecystokinin-A receptor
  • Circadian rhythm
  • Clock
  • Lipid digestion
  • Lipogenesis
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Oishi, K., Atsumi, G. I., Sugiyama, S., Kodomari, I., Kasamatsu, M., Machida, K., & Ishida, N. (2006). Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice. FEBS Letters, 580(1), 127-130. https://doi.org/10.1016/j.febslet.2005.11.063