Dissolution behavior of vaterite spherulite in solutions containing phosphate ions

Yuki Sugiura, Kazuo Onuma, Masahiro Nagao, Koichi Momma, Yuki Kimura, Atsushi Yamazaki

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Vaterite is a crystalline polymorph of calcium carbonate that exhibits low stability in comparison with the other crystalline polymorphs of calcium carbonate. It often assumes a spherical shape. The physical properties of vaterite are utilized in advanced biomaterials such as drug delivery systems (DDSs). The potential application of vaterite in DDSs demands a comprehensive understanding of its dissolution rate as a function of PO4concentration. Using in situ optical studies, we analyzed the dissolution behavior of vaterite in a simulated PO4-containing biogenic environment. The varying physicality (i.e., the pseudo-physiological conditions) of vaterite were investigated using high-resolution cryogenic transmission electron microscopy and small-angle X-ray scattering. In addition, we measured the PO4/Ca ratio in each part of vaterite spherulites using field-emission scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy and inductively coupled plasma atomic emission spectrometry. We categorized the vaterite spherulites into three parts® the shell, mantle, and core parts® on the basis of their dissolution behavior and PO4response. The PO4response to the dissolution dynamics increases toward the outer part, although the adsorption rate decreases in the presence of PO4and PO4fluorescence materials. The composition of the shell part was nearly identical to that of ideal vaterite, whereas the inner part exhibited a high C/Ca ratio and a poorly crystalline phase referred to as vaterite-like material. The dissolution rate of each part was 0.231.58nm/ s (shell), 0.633.19nm/ s (mantle), and 1.385.71 nm/s (core). The vaterite and vaterite-like materials were further identified according to their composition and particle size distribution.

    Original languageEnglish
    Pages (from-to)679-687
    Number of pages9
    JournalNippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
    Volume122
    Issue number1428
    DOIs
    Publication statusPublished - 2014 Aug 1

    Fingerprint

    spherulites
    Calcium Carbonate
    phosphates
    dissolving
    Dissolution
    Phosphates
    Ions
    calcium carbonates
    Calcium carbonate
    ions
    Crystalline materials
    Polymorphism
    delivery
    Earth mantle
    drugs
    Inductively coupled plasma
    X ray scattering
    Chemical analysis
    particle size distribution
    Biomaterials

    Keywords

    • Biomaterial
    • Calcium carbonate
    • Drug delivery systems
    • Phosphate
    • Spherulite
    • Vaterite

    ASJC Scopus subject areas

    • Ceramics and Composites
    • Materials Chemistry
    • Chemistry(all)
    • Condensed Matter Physics

    Cite this

    Dissolution behavior of vaterite spherulite in solutions containing phosphate ions. / Sugiura, Yuki; Onuma, Kazuo; Nagao, Masahiro; Momma, Koichi; Kimura, Yuki; Yamazaki, Atsushi.

    In: Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan, Vol. 122, No. 1428, 01.08.2014, p. 679-687.

    Research output: Contribution to journalArticle

    Sugiura, Yuki ; Onuma, Kazuo ; Nagao, Masahiro ; Momma, Koichi ; Kimura, Yuki ; Yamazaki, Atsushi. / Dissolution behavior of vaterite spherulite in solutions containing phosphate ions. In: Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan. 2014 ; Vol. 122, No. 1428. pp. 679-687.
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    AU - Onuma, Kazuo

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    AU - Kimura, Yuki

    AU - Yamazaki, Atsushi

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