Distribution of polymorphic gene duplication at the Gpdh locus in natural populations of Drosophila melanogaster

A. Koga, H. Baba, S. Kusakabe, Masahira Hattori, T. Mukai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The glycerol-3-phosphate dehydrogenase (GPDH, E.C. 1.1.1.8) gene of Drosophila melanogaster contains a tandem duplication of a 4.5-kb-long DNA fragment. Survey of the Gpdh gene region by the Southern blot analysis revealed the following features of this gene duplication: (1) The duplication was not observed in chromosome lines that carry In(2L)t, a cosmopolitan chromosomal inversion in this species. The duplication and the inversion are in linkage disequilibrium. (2) The duplication is polymorphic in the Japan and US natural populations examined. Its frequency is 0.26 on an average in In(2L)t-free chromosomes. (3) Triplication is absent or has not become frequent in the populations surveyed. Possible evolutionary factors of this duplication polymorphism are discussed.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalJournal of Molecular Evolution
Volume36
Issue number6
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Gene Duplication
gene duplication
Drosophila melanogaster
glycerol-3-phosphate dehydrogenase (NAD)
Genes
Chromosomes
glycerol-3-phosphate dehydrogenase
Glycerolphosphate Dehydrogenase
chromosomes
loci
gene
chromosome
Linkage Disequilibrium
linkage disequilibrium
Southern Blotting
Southern blotting
Population
Japan
genes
genetic polymorphism

Keywords

  • Drosophila melanogaster
  • Gene duplication
  • Gpdh gene
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Distribution of polymorphic gene duplication at the Gpdh locus in natural populations of Drosophila melanogaster. / Koga, A.; Baba, H.; Kusakabe, S.; Hattori, Masahira; Mukai, T.

In: Journal of Molecular Evolution, Vol. 36, No. 6, 1993, p. 532-535.

Research output: Contribution to journalArticle

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AU - Mukai, T.

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