Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Teppei Koyama, Shogo Haraguchi, Hubert Vaudry, Kazuyoshi Tsutsui

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    9 Citations (Scopus)

    Abstract

    We recently identified 7α-hydroxypregnenolone as a novel amphibian neurosteroid stimulating locomotor activity in newts. Because male newts show marked diurnal changes in locomotor activity, we hypothesized that 7α-hydroxypregnenolone may be a key factor for the induction of diurnal changes in locomotor activity in male newts. In this study, we found diurnal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts, which paralleled locomotor activity. Interestingly, the production of 7α-hydroxypregnenolone in the male newt brain increased during the dark phase when locomotor activity of males was high.

    Original languageEnglish
    Title of host publicationAnnals of the New York Academy of Sciences
    Pages444-447
    Number of pages4
    Volume1163
    DOIs
    Publication statusPublished - 2009 Apr

    Publication series

    NameAnnals of the New York Academy of Sciences
    Volume1163
    ISSN (Print)00778923
    ISSN (Electronic)17496632

    Keywords

    • 7α-hydroxypregnenolone
    • Diurnal changes
    • Locomotor activity
    • Neurosteroids
    • Newts

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Fingerprint Dive into the research topics of 'Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts'. Together they form a unique fingerprint.

  • Cite this

    Koyama, T., Haraguchi, S., Vaudry, H., & Tsutsui, K. (2009). Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts. In Annals of the New York Academy of Sciences (Vol. 1163, pp. 444-447). (Annals of the New York Academy of Sciences; Vol. 1163). https://doi.org/10.1111/j.1749-6632.2008.03622.x