DNA-binding properties of heavy-metal complexes and consequences of structural changes

Tasuku Ito, Tadashi Yamaguchi, Clifford P. Kubiak

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An overview is presented of the key role for heavy-metal compounds in medicine with a focus on DNA binding, and on Pt compounds used in treatment of cancer. Molecular aspects of the mechanism of action are reviewed in more detail and the consequences of structural distortions will be elucidated.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalMacromolecular Symposia
Volume156
Publication statusPublished - 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

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