DNA-binding properties of heavy-metal complexes and consequences of structural changes

Tasuku Ito, Tadashi Yamaguchi, Clifford P. Kubiak

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An overview is presented of the key role for heavy-metal compounds in medicine with a focus on DNA binding, and on Pt compounds used in treatment of cancer. Molecular aspects of the mechanism of action are reviewed in more detail and the consequences of structural distortions will be elucidated.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalMacromolecular Symposia
Volume156
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Heavy metal compounds
metal compounds
Coordination Complexes
heavy metals
Metal complexes
Heavy Metals
medicine
Heavy metals
Medicine
DNA
deoxyribonucleic acid
cancer

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

DNA-binding properties of heavy-metal complexes and consequences of structural changes. / Ito, Tasuku; Yamaguchi, Tadashi; Kubiak, Clifford P.

In: Macromolecular Symposia, Vol. 156, 2000, p. 277-284.

Research output: Contribution to journalArticle

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