DNA methylation profiles of CpG islands for cellular differentiation and development in mammals

K. Shiota

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

DNA methylation has been implicated in mammalian development. Transcription units contain CpG islands, but expression of CpG island associated genes in normal tissues was not believed to be controlled by DNA methylation. There are, however, numerous CpG islands containing tissue-dependent and differentially methylated regions (T-DMR), which are potential methylation sites in normal cells and tissues. Genomic scanning which focused on T-DMRs in CpG islands revealed that the DNA methylation profile of each cell/tissue is more complicated than previously considered. Differentiation of cells is associated with both methylation and demethylation, which occur at multiple loci. The epigenetic system characterized by DNA methylation requires cells to memorize gene expression patterns, thus, standardizing cellular phenotypes.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalCytogenetic and Genome Research
Volume105
Issue number2-4
DOIs
Publication statusPublished - 2004
Externally publishedYes

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CpG Islands
DNA Methylation
Mammals
Methylation
Epigenomics
Cell Differentiation
Phenotype
Gene Expression
Genes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

DNA methylation profiles of CpG islands for cellular differentiation and development in mammals. / Shiota, K.

In: Cytogenetic and Genome Research, Vol. 105, No. 2-4, 2004, p. 325-334.

Research output: Contribution to journalArticle

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