Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults

Tomohito Hamazaki, Shigeki Sawazaki, Etsuko Asaoka, Miho Itomura, Yutaka Mizushima, Kazunaga Yazawa, Toyomi Kuwamori, Masashi Kobayashi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Fish oils, purified eicosapentaenoic acid and docosahexaenoic acid (DHA) have been reported to improve blood lipid concentrations, especially those of triglycerides in humans. However, to our knowledge there have been no double- blind studies investigating the effects of DHA-rich fish oil on blood lipid concentrations. Therefore, we conducted a placebo-controlled double-blind study. Twenty-four healthy, normolipidemic young adults took either DHA-rich fish oil capsules containing 1.5-1.8 g of DHA or control oil capsules containing 97% soybean oil and 3% fish oil for 13 wk. Blood samples were taken at the start and end of the study, and serum lipids concentrations were compared. There were no significant changes over time in the DHA group in the following serum lipids: total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, lipoprotein(a), and apolipoproteins A1 and B. In contrast, apolipoprotein A1 concentrations slightly (10%) but significantly increased over time in the control group. Docosahexaenoic acid at a dose of less than 2 g/d did not change serum lipid concentrations of normolipidemic subjects. The effects of DHA in hyperlipidemic patients remain to be investigated in a double-blind study.

Original languageEnglish
Pages (from-to)2784-2789
Number of pages6
JournalJournal of Nutrition
Volume126
Issue number11
Publication statusPublished - 1996 Nov
Externally publishedYes

Fingerprint

fatty fish
Docosahexaenoic Acids
Fish Oils
docosahexaenoic acid
young adults
blood lipids
Young Adult
Lipids
Serum
Double-Blind Method
apolipoproteins
Apolipoprotein A-I
fish oils
Capsules
triacylglycerols
Soybean Oil
Lipoprotein(a)
Eicosapentaenoic Acid
Apolipoproteins B
eicosapentaenoic acid

Keywords

  • cholesterol
  • docosahexaenoic acid
  • humans
  • lipids
  • lipoprotein(a)
  • serum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Hamazaki, T., Sawazaki, S., Asaoka, E., Itomura, M., Mizushima, Y., Yazawa, K., ... Kobayashi, M. (1996). Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. Journal of Nutrition, 126(11), 2784-2789.

Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. / Hamazaki, Tomohito; Sawazaki, Shigeki; Asaoka, Etsuko; Itomura, Miho; Mizushima, Yutaka; Yazawa, Kazunaga; Kuwamori, Toyomi; Kobayashi, Masashi.

In: Journal of Nutrition, Vol. 126, No. 11, 11.1996, p. 2784-2789.

Research output: Contribution to journalArticle

Hamazaki, T, Sawazaki, S, Asaoka, E, Itomura, M, Mizushima, Y, Yazawa, K, Kuwamori, T & Kobayashi, M 1996, 'Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults', Journal of Nutrition, vol. 126, no. 11, pp. 2784-2789.
Hamazaki T, Sawazaki S, Asaoka E, Itomura M, Mizushima Y, Yazawa K et al. Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. Journal of Nutrition. 1996 Nov;126(11):2784-2789.
Hamazaki, Tomohito ; Sawazaki, Shigeki ; Asaoka, Etsuko ; Itomura, Miho ; Mizushima, Yutaka ; Yazawa, Kazunaga ; Kuwamori, Toyomi ; Kobayashi, Masashi. / Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. In: Journal of Nutrition. 1996 ; Vol. 126, No. 11. pp. 2784-2789.
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